About: Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export

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About: Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export
Creator	Yang, Kai Chen, Xinwen Pei, Rongjuan Zhao, Han Chen, Jizheng Hu, Xue Hu, Yangyang Mu, Jingfang Wang, Yun Wu, Chunchen Zhao, He Zhou, Yuan Van Oers, Monique Zhang, Zhang, Mu
Source	Medline; PMC
abstract	Actin, nucleation-promoting factors (NPFs), and the actin-related protein 2/3 complex (Arp2/3) are key elements of the cellular actin polymerization machinery. With nuclear actin polymerization implicated in ever-expanding biological processes and the discovery of the nuclear import mechanisms of actin and NPFs, determining Arp2/3 nucleo-cytoplasmic shuttling mechanism is important for understanding the function of nuclear actin. A unique feature of alphabaculovirus infection of insect cells is the robust nuclear accumulation of Arp2/3, which induces actin polymerization in the nucleus to assist in virus replication. We found that Ac34, a viral late gene product encoded by the alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), is involved in Arp2/3 nuclear accumulation during virus infection. Further assays revealed that the subcellular distribution of Arp2/3 under steady-state conditions is controlled by chromosomal maintenance 1 (CRM1)-dependent nuclear export. Upon AcMNPV infection, Ac34 inhibits CRM1 pathway and leads to Arp2/3 retention in the nucleus.
has issue date	2016-11-01(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1005994
bibo:pmid	27802336
has license	cc-by
sha1sum (hex)	9586f483c1144f2e1b3105d587b826f467d02832
schema:url	https://doi.org/10.1371/journal.ppat.1005994
resource representing a document's title	Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export
has PubMed Central identifier	PMC5089780
has PubMed identifier	27802336
schema:publication	PLoS Pathog
resource representing a document's body	covid:9586f483c1144f2e1b3105d587b826f467d02832#body_text
is schema:about of	named entity 'protein' named entity 'polymerization' named entity 'Actin' named entity 'Arp2/3' named entity 'polymerization' named entity 'machinery' named entity 'retention' named entity 'actin' named entity 'NUCLEUS' named entity 'VIRUS INFECTION' named entity 'KEY' named entity 'ROBUST' named entity 'NUCLEAR IMPORT' named entity 'ACTIN-RELATED PROTEIN 2' named entity 'MAINTENANCE' named entity 'COMPLEX' named entity 'LEADS' named entity 'CELLS' named entity 'ENCODED' named entity 'UNDERSTANDING' named entity 'DEPENDENT' named entity 'PROMOTING' named entity 'CELLULAR' named entity 'STEADY-STATE' named entity 'MACHINERY' named entity 'RETENTION' named entity 'INVOLVED' named entity 'MECHANISMS' named entity 'FUNCTION' named entity 'FEATURE' named entity 'ACTIN' named entity 'NUCLEO' named entity 'NUCLEATION' named entity 'IMPORTANT' named entity 'CHROMOSOMAL' named entity 'ACCUMULATION' named entity 'REVEALED' named entity 'INSECT' named entity 'CONTROLLED BY' named entity 'LATE' named entity 'INFECTION' named entity 'NUCLEAR' named entity 'EXPANDING' named entity 'AUTOGRAPHA CALIFORNICA MULTIPLE NUCLEOPOLYHEDROVIRUS' named entity 'ACTIN-RELATED PROTEIN 2' named entity 'ELEMENTS' named entity 'VIRAL' named entity 'PATHWAY' named entity 'ACMNPV' named entity 'CYTOPLASMIC' named entity 'UNIQUE' named entity 'NUCLEAR EXPORT' named entity 'CELLULAR' named entity 'NUCLEAR EXPORT' named entity 'OPEN' named entity 'ARP2' named entity 'GENE PRODUCT' named entity 'COMPLEX' named entity 'DEPENDENT' named entity 'PROTEIN ' named entity 'RETAINS' named entity 'AUTOGRAPHA CALIFORNICA MULTIPLE NUCLEOPOLYHEDROVIRUS' named entity 'DISCOVERY' named entity 'ACTIN POLYMERIZATION' named entity 'CONDITIONS' named entity 'BIOLOGICAL PROCESSES' named entity 'VIRUS REPLICATION'

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