About: miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells

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About: miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells
Creator	Zhang, Jing An, Jing Fan, Dongying Gao, Na Wei, Jianchun Wu, Na
Source	Elsevier; Medline; PMC
abstract	The pathogenesis of dengue virus (DENV) infection is not completely understood. Endothelial cells may act as a target of the virus and be involved in disease pathogenesis. Therefore, the identification of host cell components involved in DENV replication would provide useful information for better understanding DENV infection. In this study, a significantly decreased level of miR-223 was found in DENV2-infected EAhy926 cells, a human endothelial-like cell line, whereas miR-223 overexpression inhibited DENV2 replication. Furthermore, we identified that miR-223 directly targeted the 3′ untranslated region (3′UTR) of the messenger RNA (mRNA) for microtubule-destabilizing protein stathmin 1 (STMN1), thereby reducing its mRNA and protein levels. The depletion of miR-223 or overexpression of STMN1 enhanced DENV2 replication, whereas the opposite (increased miR-223 or decreased STMN1) suppressed DENV2 replication, indicating that miR-223 down-regulates STMN1 expression by targeting the 3′UTR of the STMN1 gene to inhibit DENV2 replication. Finally, we demonstrated that two transcription factors, C/EBPα and E2F1, are involved in the regulation of miR-223 levels after DENV2 infection in EAhy926 cells. Collectively, our results suggest that miR-223 may act as a novel antiviral factor, which may open an avenue to limit DENV infection.
has issue date	2014-08-30(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2014.08.011
bibo:pmid	25181337
has license	no-cc
sha1sum (hex)	9618ed717697f4aa77f65da0baada1f304a5d919
schema:url	https://doi.org/10.1016/j.micinf.2014.08.011
resource representing a document's title	miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells
has PubMed Central identifier	PMC7110837
has PubMed identifier	25181337
schema:publication	Microbes Infect
resource representing a document's body	covid:9618ed717697f4aa77f65da0baada1f304a5d919#body_text
is schema:about of	named entity 'infection' named entity 'E2F1' named entity 'involved' named entity 'Therefore' named entity 'REGULATION' named entity 'DISEASE' named entity 'ENDOTHELIAL CELLS' named entity 'MIR-223' named entity 'DECREASED' named entity 'MICROTUBULE' named entity 'STATHMIN 1' named entity 'OVEREXPRESSION' named entity 'COMPLETELY' named entity 'DENV2-' named entity 'DEPLETION' named entity 'TARGETING' named entity 'NOVEL' named entity 'STUDY' named entity 'LEVELS' named entity 'MRNA' named entity 'CELLS' named entity 'BETTER' covid:arg/9618ed717697f4aa77f65da0baada1f304a5d919 named entity 'AVENUE' named entity 'MIR-223' named entity 'CELLS' named entity 'CELL COMPONENTS' named entity 'FACTOR' named entity 'PATHOGENESIS' named entity 'HUMAN' named entity 'ENHANCED' named entity 'REGULATING' named entity 'VIRUS REPLICATION' named entity 'PROTEIN ' named entity 'MICROTUBULE' named entity 'DENGUE VIRUS' named entity 'CELL LINE' named entity 'LEVEL' named entity 'LIKE' named entity 'PROTEIN LEVELS' named entity 'INFECTED' named entity 'DIRECTLY' named entity 'STMN1' named entity 'INHIBITED' named entity 'USEFUL INFORMATION' named entity 'EXPRESSION' named entity 'REPLICATION' named entity 'EAHY926' named entity 'OPPOSITE' named entity 'ACT' named entity 'FOUND' named entity 'ANTIVIRAL' named entity 'EAHY926' named entity 'STMN1' named entity 'INFECTION' named entity '283' named entity 'IDENTIFICATION' named entity 'DENGUE VIRUS' named entity 'OUR' named entity 'VIRUS' named entity 'TARGET' named entity 'PROTEIN ' named entity 'TRANSCRIPTION FACTORS' named entity 'UNTRANSLATED REGION' named entity 'SUPPRESSED' named entity 'REDUCING' named entity 'UNDERSTOOD' named entity 'HOST CELL' named entity 'IDENTIFIED' named entity 'UTR' named entity 'ENDOTHELIAL' named entity 'INVOLVED' named entity 'UNDERSTANDING' named entity 'MESSENGER RNA' named entity 'SUGGEST' named entity 'PROVIDE'

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