About: Programmed Ribosomal Frameshift Alters Expression of West Nile Virus Genes and Facilitates Virus Replication in Birds and Mosquitoes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Programmed Ribosomal Frameshift Alters Expression of West Nile Virus Genes and Facilitates Virus Replication in Birds and Mosquitoes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Programmed Ribosomal Frameshift Alters Expression of West Nile Virus Genes and Facilitates Virus Replication in Birds and Mosquitoes
Creator	Bosco-Lauth, A Du, F Hall-Mendelin, S Melian, E Owens, N
Source	Medline; PMC
abstract	West Nile virus (WNV) is a human pathogen of significant medical importance with close to 40,000 cases of encephalitis and more than 1,600 deaths reported in the US alone since its first emergence in New York in 1999. Previous studies identified a motif in the beginning of non-structural gene NS2A of encephalitic flaviviruses including WNV which induces programmed −1 ribosomal frameshift (PRF) resulting in production of an additional NS protein NS1′. We have previously demonstrated that mutant WNV with abolished PRF was attenuated in mice. Here we have extended our previous observations by showing that PRF does not appear to have a significant role in virus replication, virion formation, and viral spread in several cell lines in vitro. However, we have also shown that PRF induces an over production of structural proteins over non-structural proteins in virus-infected cells and that mutation abolishing PRF is present in ∼11% of the wild type virus population. In vivo experiments in house sparrows using wild type and PRF mutant of New York 99 strain of WNV viruses showed some attenuation for the PRF mutant virus. Moreover, PRF mutant of Kunjin strain of WNV showed significant decrease compared to wild type virus infection in dissemination of the virus from the midgut through the haemocoel, and ultimately the capacity of infected mosquitoes to transmit virus. Thus our results demonstrate an important role for PRF in regulating expression of viral genes and consequently virus replication in avian and mosquito hosts.
has issue date	2014-11-06(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1004447
bibo:pmid	25375107
has license	cc0
sha1sum (hex)	96456a955d56878dc1e53c0feeb14bf307518b17
schema:url	https://doi.org/10.1371/journal.ppat.1004447
resource representing a document's title	Programmed Ribosomal Frameshift Alters Expression of West Nile Virus Genes and Facilitates Virus Replication in Birds and Mosquitoes
has PubMed Central identifier	PMC4223154
has PubMed identifier	25375107
schema:publication	PLoS Pathog
resource representing a document's body	covid:96456a955d56878dc1e53c0feeb14bf307518b17#body_text
is schema:about of	named entity 'MOSQUITOES' named entity 'WNV' named entity 'infected' named entity 'viruses' named entity 'replication' named entity 'New York' named entity 'virus' named entity 'GENES' named entity 'MUTANT' named entity '40%' named entity 'RESULTS' named entity 'SPARROWS' named entity 'WEST NILE VIRUS' named entity 'PROTEIN ' named entity 'DECREASE' named entity 'MEDICAL' named entity 'INCLUDING' named entity 'APPEAR' named entity 'FLAVIVIRUSES' named entity 'USING' named entity 'HOSTS' named entity 'VIRUS REPLICATION' named entity 'MUTATION' named entity 'ATTENUATION' named entity 'VIRUSES' named entity 'NON-' named entity 'CELLS' named entity 'STUDIES' named entity 'ABOLISHED' named entity 'VIRAL GENES' named entity 'MOSQUITOES' named entity 'WNV' named entity 'HERE' named entity 'HOUSE' named entity 'IMPORTANT' named entity 'TO TRANSMIT' named entity 'BEGINNING' named entity 'TYPE VIRUS' named entity 'WILD TYPE' named entity 'DOES NOT' named entity 'RESULTING IN' named entity 'STRUCTURAL PROTEINS' named entity 'SPREAD' named entity 'VIRUS POPULATION' named entity 'HAEMOCOEL' named entity 'OUR' named entity 'VIRUS REPLICATION' named entity 'VIRAL' named entity 'DEATHS' named entity 'NONSTRUCTURAL PROTEINS' named entity 'MOTIF' named entity 'CASES' named entity 'VIRUS INFECTION' named entity 'MORE THAN' named entity 'ADDITIONAL' named entity 'EXPRESSION' named entity 'WEST NILE VIRUS' named entity 'RIBOSOMAL FRAMESHIFT' named entity 'BIRDS' named entity 'VIRUS' named entity 'CAPACITY' named entity 'SIGNIFICANT' named entity 'INFECTED' named entity 'PRF' named entity 'AVIAN' named entity 'STRUCTURAL GENE' named entity 'PRESENT' named entity 'RIBOSOMAL FRAMESHIFT' named entity 'REPORTED' named entity 'IN VIVO' named entity 'NS2A' named entity 'EXPERIMENTS' named entity 'EXTENDED' named entity 'PATHOGEN' named entity 'EXPRESSION' named entity 'ITS' named entity 'EMERGENCE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software