About: Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets

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About: Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets
Creator	Kuiken, Thijs Osterhaus, Albert Poon, Leo Reperant, Leslie Stittelaar, Koert Van Amerongen, Geert Van Den Brand, Judith De Waal, Leon
Source	Medline; PMC
abstract	Humans may be infected by different influenza A viruses—seasonal, pandemic, and zoonotic—which differ in presentation from mild upper respiratory tract disease to severe and sometimes fatal pneumonia with extra-respiratory spread. Differences in spatial and temporal dynamics of these infections are poorly understood. Therefore, we inoculated ferrets with seasonal H3N2, pandemic H1N1 (pH1N1), and highly pathogenic avian H5N1 influenza virus and performed detailed virological and pathological analyses at time points from 0.5 to 14 days post inoculation (dpi), as well as describing clinical signs and hematological parameters. H3N2 infection was restricted to the nose and peaked at 1 dpi. pH1N1 infection also peaked at 1 dpi, but occurred at similar levels throughout the respiratory tract. H5N1 infection occurred predominantly in the alveoli, where it peaked for a longer period, from 1 to 3 dpi. The associated lesions followed the same spatial distribution as virus infection, but their severity peaked between 1 and 6 days later. Neutrophil and monocyte counts in peripheral blood correlated with inflammatory cell influx in the alveoli. Of the different parameters used to measure lower respiratory tract disease, relative lung weight and affected lung tissue allowed the best quantitative distinction between the virus groups. There was extra-respiratory spread to more tissues—including the central nervous system—for H5N1 infection than for pH1N1 infection, and to none for H3N2 infection. This study shows that seasonal, pandemic, and zoonotic influenza viruses differ strongly in the spatial and temporal dynamics of infection in the respiratory tract and extra-respiratory tissues of ferrets.
has issue date	2012-08-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0042343
bibo:pmid	22905124
has license	cc-by
sha1sum (hex)	965f06d2f9a87b69f59b1656c979e04eaa5d75be
schema:url	https://doi.org/10.1371/journal.pone.0042343
resource representing a document's title	Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets
has PubMed Central identifier	PMC3414522
has PubMed identifier	22905124
schema:publication	PLoS One
resource representing a document's body	covid:965f06d2f9a87b69f59b1656c979e04eaa5d75be#body_text
is schema:about of	named entity 'INFECTIONS' covid:arg/965f06d2f9a87b69f59b1656c979e04eaa5d75be named entity 'PATHOGENIC' named entity 'DPI' named entity 'BUT' named entity 'H1N1' named entity 'RESPIRATORY' named entity 'SEVERITY' named entity 'POORLY' named entity 'PERIPHERAL BLOOD' named entity 'SPREAD' named entity 'INFLUENZA VIRUS' named entity 'UPPER RESPIRATORY TRACT DISEASE' named entity 'INFECTIONS' named entity 'H5N1 INFLUENZA' named entity 'INCLUDING' named entity 'PEAKED' named entity 'UNDERSTOOD' named entity 'SIMILAR' named entity 'VIRUS' named entity 'LUNG WEIGHT' named entity 'RELATIVE' named entity 'FERRETS' named entity 'NEUTROPHIL' named entity 'WHERE' named entity 'VIRUS INFECTION' named entity 'LATER' named entity 'TIME' named entity 'DETAILED' named entity 'LOWER RESPIRATORY TRACT DISEASE' named entity 'HEMATOLOGICAL PARAMETERS' named entity 'AS VIRUS' named entity 'FATAL' named entity 'H5N1' named entity 'NOSE' named entity 'INFECTED' named entity 'EXTRA' named entity 'INFLAMMATORY CELL' named entity 'SEASONAL' named entity 'VIRUSES' named entity 'OCCURRED' named entity 'AVIAN' named entity '1 TO 3' named entity 'RESPIRATORY TRACT' named entity 'PRESENTATION' named entity 'TEMPORAL' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'LESIONS' named entity 'DIFFERENT' named entity 'RESTRICTED' named entity 'THEIR' named entity 'ASSOCIATED' named entity 'THESE' named entity 'DAYS' named entity 'BEST' named entity 'PATHOLOGICAL' named entity 'ALLOWED' named entity 'DESCRIBING' named entity 'USED' named entity 'MILD' named entity 'VIROLOGICAL' named entity 'SEASONAL' named entity 'PANDEMIC' named entity 'H1N1' named entity 'COMPARISON' named entity 'SPATIAL' named entity 'H3N2' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'DYNAMICS' named entity 'INOCULATION' named entity 'PERFORMED' named entity 'AFFECTED' named entity 'FOLLOWED' named entity '0.5'

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