About: Interleukin-35 as an Emerging Player in Tumor Microenvironment

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin-35 as an Emerging Player in Tumor Microenvironment
Creator	Yan, Dan Kan, Quancheng Xue, Wenhua
Source	Medline; PMC
abstract	IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.
has issue date	2019-05-12(xsd:dateTime)
bibo:doi	10.7150/jca.29170
bibo:pmid	31205568
has license	cc-by-nc
sha1sum (hex)	9660e4d54d854be62dc2e3ec086d1132a741efd9
schema:url	https://doi.org/10.7150/jca.29170
resource representing a document's title	Interleukin-35 as an Emerging Player in Tumor Microenvironment
has PubMed Central identifier	PMC6548173
has PubMed identifier	31205568
schema:publication	J Cancer
resource representing a document's body	covid:9660e4d54d854be62dc2e3ec086d1132a741efd9#body_text
is schema:about of	named entity 'REGULATORY T CELLS' named entity 'IMMUNE SYSTEM' named entity 'ANIMAL MODELS' named entity 'LIMITED' named entity 'VARIOUS' named entity 'REVIEW' named entity 'SEEN' named entity 'EXACT' named entity 'HAVE' named entity 'STUDIES' named entity 'FUNCTIONS' named entity 'A GREAT DEAL' named entity 'IDEA' named entity 'PRECISE' named entity 'PURPOSE' named entity 'SEARCH' named entity 'MANIFESTED' named entity 'INCREASED' named entity 'REPORTS' named entity 'DEVELOPMENT' named entity 'CONTINUOUS' named entity 'ITS' named entity 'SIGNAL TRANSDUCTION' named entity 'inhibitory' named entity 'symphony' named entity 'precise' named entity 'CANCER' named entity 'DENIED' named entity 'INTERLEUKIN-35' named entity 'SEPARATE' named entity 'FAMILY' named entity 'SCIENTIFIC DATA' named entity 'IL-35' named entity 'CONTEXT' named entity 'TUMOR MICROENVIRONMENT' named entity 'PROTEIN ' named entity 'SUPPRESSIVE' named entity 'DECADE' named entity 'ACTIONS' named entity 'CELLS GROWTH' named entity 'IL-12' named entity 'TUMOR MICROENVIRONMENT' named entity 'REPORTED' named entity 'FORMATION' named entity 'INTEREST' named entity 'PRODUCING' named entity 'TREG' named entity 'SCIENTIFIC' named entity 'SUBJECT' named entity 'SUCCESS' named entity 'THERAPIES' named entity 'PLAYS' named entity 'CONFIRMED' named entity 'MEMBER OF' named entity 'CANCERS' named entity 'CARRIED' named entity 'TH17 CELLS' named entity 'ROLE' named entity 'INHIBITORY' named entity 'subunits' named entity 'context' named entity 'subject' named entity 'deal' named entity 'IL-12' named entity 'scientific' named entity 'therapies' named entity 'Various' named entity 'Tumor' named entity 'IL-35' named entity 'IL-35' named entity 'animal models' named entity 'IL-35' named entity 'Treg' named entity 'Th17 cells' named entity 'Interleukin-35' named entity 'tumor suppressor' named entity 'endogenous' named entity 'IL-35' named entity 'colon cancer'

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