About: Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I

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About: Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I
Creator	Bernard, Julie Lamoureux, Annie Bré, Michel Mé, Emilie Phane Biacchesi, Sté
Source	Medline; PMC
abstract	Viral infections are detected in most cases by the host innate immune system through pattern-recognition receptors (PRR), the sensors for pathogen-associated molecular patterns (PAMPs), which induce the production of cytokines, such as type I interferons (IFN). Recent identification in mammalian and teleost fish of cytoplasmic viral RNA sensors, RIG-I-like receptors (RLRs), and their mitochondrial adaptor: the mitochondrial antiviral signaling (MAVS) protein, also called IPS-1, highlight their important role in the induction of IFN at the early stage of a virus infection. More recently, an endoplasmic reticulum (ER) adaptor: the stimulator of interferon genes (STING) protein, also called MITA, ERIS and MPYS, has been shown to play a pivotal role in response to both non-self-cytosolic RNA and dsDNA. In this study, we cloned STING cDNAs from zebrafish and showed that it was an ortholog to mammalian STING. We demonstrated that overexpression of this ER protein in fish cells led to a constitutive induction of IFN and interferon-stimulated genes (ISGs). STING-overexpressing cells were almost fully protected against RNA virus infection with a strong inhibition of both DNA and RNA virus replication. In addition, we found that together with MAVS, STING was an important player in the RIG-I IFN-inducing pathway. This report provides the demonstration that teleost fish possess a functional RLR pathway in which MAVS and STING are downstream signaling molecules of RIG-I. The Sequences presented in this article have been submitted to GenBank under accession numbers: Zebrafish STING (HE856619); EPC STING (HE856620); EPC IRF3 (HE856621); EPC IFN promoter (HE856618).
has issue date	2012-10-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0047737
bibo:pmid	23091644
has license	cc-by
sha1sum (hex)	96782ada9704aca0076d39f6e2592c521d8a5383
schema:url	https://doi.org/10.1371/journal.pone.0047737
resource representing a document's title	Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I
has PubMed Central identifier	PMC3473018
has PubMed identifier	23091644
schema:publication	PLoS One
resource representing a document's body	covid:96782ada9704aca0076d39f6e2592c521d8a5383#body_text
is schema:about of	named entity 'STING' named entity 'cloned' named entity 'replication' named entity 'MAVS' named entity 'genes' named entity 'protein' named entity 'play' named entity 'MAVS' named entity 'RIG-I' covid:arg/96782ada9704aca0076d39f6e2592c521d8a5383 named entity 'MAVS' named entity 'INNATE IMMUNE SYSTEM' named entity 'CASES' named entity 'VIRAL INFECTIONS' named entity 'FISH' named entity 'ACCESSION NUMBERS' named entity 'IFN' named entity 'INDUCING' named entity 'IPS-1' named entity 'TYPE I INTERFERONS' named entity 'VIRUS REPLICATION' named entity 'VIRAL RNA' named entity 'ZEBRAFISH' named entity 'PATTERNS' named entity 'RECENTLY' named entity 'PRODUCTION' named entity 'SENSORS' named entity 'FUNCTIONAL' named entity 'PATHOGEN' named entity 'SIGNALING' named entity 'STUDY' named entity 'IMPORTANT' named entity 'MITA' named entity 'STRONG' named entity 'DETECTED' named entity 'OVEREXPRESSION' named entity 'FULLY' named entity 'HAVE' named entity 'RLR' named entity 'EPC' named entity 'REPORT' named entity 'LIKE' named entity 'PATTERN' named entity 'FOUND' named entity 'ORTHOLOG' named entity 'SUBMITTED' named entity 'CYTOPLASMIC' named entity 'PRESENTED' named entity 'STING' named entity 'INHIBITION' named entity 'CYTOSOLIC' named entity 'RECENT' named entity 'POSSESS' named entity 'ENDOPLASMIC RETICULUM' named entity 'NON-SELF' named entity 'ASSOCIATED' named entity 'ERIS' named entity 'INDUCTION' named entity 'ANTIVIRAL' named entity 'CELLS' named entity 'SIGNALING MOLECULES' named entity 'HOST' named entity 'MITOCHONDRIAL' named entity 'RECOGNITION' named entity 'ALMOST' named entity 'INDUCE' named entity 'RECEPTORS' named entity 'INDUCTION' named entity 'GENES' named entity 'MAMMALIAN' named entity 'TELEOST FISH' named entity 'CLONED' named entity 'CYTOKINES' named entity 'RIG-I' named entity 'FISH' named entity 'CONTRIBUTE ' named entity 'MAVS'

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