About: A Novel Virus Causes Scale Drop Disease in Lates calcarifer

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About: A Novel Virus Causes Scale Drop Disease in Lates calcarifer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Virus Causes Scale Drop Disease in Lates calcarifer
Creator	Deijs, Martin Biermann, Yvonne Guelen, Lars Miyata, Masato Schrier, Carla Simmelink, Bartjan Chang, Siow Ng, Van Der Hoek, Lia Van Lent, Jan De Groof, Ad De Ronde, Anthony Kah, Sing Luc Grisez, Van Der Wal, Yorick Van Grinsven, Lotte
Source	PMC
abstract	From 1992 onwards, outbreaks of a previously unknown illness have been reported in Asian seabass (Lates calcarifer) kept in maricultures in Southeast Asia. The most striking symptom of this emerging disease is the loss of scales. It was referred to as scale drop syndrome, but the etiology remained enigmatic. By using a next-generation virus discovery technique, VIDISCA-454, sequences of an unknown virus were detected in serum of diseased fish. The near complete genome sequence of the virus was determined, which shows a unique genome organization, and low levels of identity to known members of the Iridoviridae. Based on homology of a series of putatively encoded proteins, the virus is a novel member of the Megalocytivirus genus of the Iridoviridae family. The virus was isolated and propagated in cell culture, where it caused a cytopathogenic effect in infected Asian seabass kidney and brain cells. Electron microscopy revealed icosahedral virions of about 140 nm, characteristic for the Iridoviridae. In vitro cultured virus induced scale drop syndrome in Asian seabass in vivo and the virus could be reisolated from these infected fish. These findings show that the virus is the causative agent for the scale drop syndrome, as each of Koch’s postulates is fulfilled. We have named the virus Scale Drop Disease Virus. Vaccines prepared from BEI- and formalin inactivated virus, as well as from E. coli produced major capsid protein provide efficacious protection against scale drop disease.
has issue date	2015-08-07(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1005074
bibo:pmid	26252390
has license	cc-by
sha1sum (hex)	96a20376534b0725c4cbd316e15d003d2183436b
schema:url	https://doi.org/10.1371/journal.ppat.1005074
resource representing a document's title	A Novel Virus Causes Scale Drop Disease in Lates calcarifer
has PubMed Central identifier	PMC4529248
has PubMed identifier	26252390
schema:publication	PLoS Pathog
resource representing a document's body	covid:96a20376534b0725c4cbd316e15d003d2183436b#body_text
is schema:about of	named entity 'VIRUS' named entity 'protein' named entity 'kidney' named entity 'genus' named entity 'Disease' named entity 'Lates calcarifer' named entity 'LATES CALCARIFER' named entity 'NAMED' covid:arg/96a20376534b0725c4cbd316e15d003d2183436b named entity 'THESE' named entity 'BRAIN CELLS' named entity 'E. COLI' named entity 'SERIES' named entity 'FINDINGS' named entity 'KIDNEY' named entity 'IDENTITY' named entity 'SERUM' named entity 'IRIDOVIRIDAE' named entity 'VIRIONS' named entity 'MEMBERS' named entity 'HOMOLOGY' named entity 'OUTBREAKS' named entity 'NOVEL' named entity 'SOUTHEAST ASIA' named entity 'NEAR COMPLETE' named entity 'DISEASE' named entity 'ASIAN SEABASS' named entity 'FAMILY' named entity 'GENOME ORGANIZATION' named entity 'BUT' named entity 'DROP' named entity 'NOVEL' named entity 'SCALE' named entity 'COULD BE' named entity 'FORMALIN' named entity 'SCALE' named entity 'DROP' named entity 'PROVIDE' named entity 'FISH' named entity 'REFERRED TO' named entity 'SYMPTOM' named entity 'DETERMINED' named entity 'TECHNIQUE' named entity 'IS A' named entity 'INACTIVATED' named entity 'CULTURED' named entity 'INFECTED' named entity 'WHERE' named entity 'CAUSATIVE AGENT' named entity 'AND BRAIN' named entity 'LOW' named entity 'VIRUS' named entity 'GENERATION' named entity 'CHARACTERISTIC' named entity 'UNKNOWN' named entity 'MEGALOCYTIVIRUS' named entity 'BEI' named entity 'REPORTED' named entity 'IN VIVO' named entity 'ENCODED' named entity 'PROTEINS' named entity 'LEVELS' named entity 'PROTEIN ' named entity 'SCALE DROP DISEASE VIRUS' named entity 'DISCOVERY' named entity 'ELECTRON MICROSCOPY'

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