About: Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

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About: Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63
Creator	Lin, Cheng-Wen Huang, Su-Hua Lin, Chen-Sheng Wang, Ching-Ying Lai, Hsueh-Chou Lin, Yu-Ping Tsai, Yu-Chi Weng, Jing-Ru Wu, Kun-Chang
Source	Elsevier; Medline; PMC
abstract	Abstract Human coronavirus NL63 (HCoV-NL63), one of the main circulating HCoVs worldwide, causes respiratory tract illnesses like runny nose, cough, bronchiolitis and pneumonia. Recently, a severe respiratory illness outbreak of HCoV-NL63 has been reported in a long-term care facility. Sambucus FormosanaNakai, a species of elderberry, is a traditional medicinal herb with anti-inflammatory and antiviral potential. The study investigated the antiviral activity of Sambucus FormosanaNakai stem ethanol extract and some phenolic acid constituents against HCoV-NL63. The extract was less cytotoxic and concentration-dependently increased anti-HCoV-NL63 activities, including cytopathicity, sub-G1 fraction, virus yield (IC50 = 1.17 μg/ml), plaque formation (IC50 = 4.67 μg/ml) and virus attachment (IC50 = 15.75 μg/ml). Among the phenolic acid constituents in Sambucus FormosanaNakai extract, caffeic acid, chlorogenic acid and gallic acid sustained the anti-HCoV-NL63 activity that was ranked in the following order of virus yield reduction: caffeic acid (IC50 = 3.54 μM) > chlorogenic acid (IC50 = 43.45 μM) > coumaric acid (IC50 = 71.48 μM). Caffeic acid significantly inhibited the replication of HCoV-NL63 in a cell-type independent manner, and specifically blocked virus attachment (IC50 = 8.1 μM). Therefore, the results revealed that Sambucus Formosana Nakai stem ethanol extract displayed the strong anti-HCoV-NL63 potential; caffeic acid could be the vital component with anti-HCoV-NL63 activity. The finding could be helpful for developing antivirals against HCoV-NL63.
has issue date	2019-11-30(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2019.197767
bibo:pmid	31560964
has license	els-covid
sha1sum (hex)	96af850175c149e1173080d114ff4aefffd98a71
schema:url	https://doi.org/10.1016/j.virusres.2019.197767
resource representing a document's title	Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63
has PubMed Central identifier	PMC7114872
has PubMed identifier	31560964
schema:publication	Virus Research
resource representing a document's body	covid:96af850175c149e1173080d114ff4aefffd98a71#body_text
is schema:about of	named entity 'pneumonia' named entity 'fraction' named entity 'activity' named entity 'extract' named entity 'Sambucus' covid:arg/96af850175c149e1173080d114ff4aefffd98a71 named entity 'Sambucus' named entity 'replication' named entity 'finding' named entity 'acid' named entity 'acid' named entity 'IC50' named entity 'Sambucus' named entity 'worldwide' named entity 'cytotoxic' named entity 'circulating' named entity 'cough' named entity 'acid' named entity 'phenolic acid' named entity 'HCoV-NL63' named entity 'chlorogenic acid' named entity 'gallic acid' named entity 'runny nose' named entity 'ethanol' named entity 'antiviral activity' named entity 'virus' named entity 'IC50' named entity 'IC50' named entity 'chlorogenic acid' named entity 'virus' named entity 'coumaric acid' named entity 'ethanol' named entity 'Antiviral activity' named entity 'activity' named entity 'plaque formation' named entity 'herpes simplex virus type 1' named entity 'interferon α' named entity 'phenolic acid' named entity '0.01' named entity 'ACE2' named entity 'chlorogenic acid' named entity 'MEM' named entity 'plaque assay' named entity 'HCoV-NL63' named entity 'cell cycle' named entity 'phenolic acid' named entity 'chlorogenic acid' named entity 'infectivity' named entity 'HCoV-NL63' named entity 'infectivity' named entity 'antiviral activity' named entity 'ferulic acid' named entity 'HCoV-NL63' named entity 'anti-inflammatory' named entity 'young children' named entity 'phenolic acid' named entity 'RNA' named entity 'inhibitory activity' named entity 'virus' named entity 'pneumonia' named entity 'chlorogenic acid' named entity 'heparan sulfate proteoglycans' named entity 'HCoV NL63' named entity 'cytotoxic' named entity 'phenolic acid' named entity 'coumaric acid' named entity 'plaque formation' named entity 'medicinal herb' named entity 'plaque formation' named entity 'virucidal' named entity 'Cambodia' named entity 'HCoV-NL63' named entity 'flow cytometry'

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