About: Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution

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About: Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution
Creator	Hiscox, Julian Matthews, David Leppard, Keith Turnell, Andrew Ah Donovan-Banfield, I
Source	Medline; PMC
abstract	Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especially complex. We used long-read direct RNA sequencing to study adenovirus transcription and splicing during infection. This revealed a previously unappreciated complexity of alternative splicing and potential for secondary initiating codon usage. Moreover, we find that most viral transcripts tend to shorten polyadenylation lengths as infection progresses. Development of an open reading frame centric bioinformatics analysis pipeline provided a deeper quantitative and qualitative understanding of adenovirus’s genetic potential. Across the viral genome adenovirus makes multiple distinctly spliced transcripts that code for the same protein. Over 11,000 different splicing patterns were recorded across the viral genome, most occurring at low levels. This low-level use of alternative splicing patterns potentially enables the virus to maximise its coding potential over evolutionary timescales.
has issue date	2020-03-13(xsd:dateTime)
bibo:doi	10.1038/s42003-020-0849-9
bibo:pmid	32170151
has license	cc-by
sha1sum (hex)	96d1423925b6930795b2ac9f2f8b48d4295f4364
schema:url	https://doi.org/10.1038/s42003-020-0849-9
resource representing a document's title	Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution
has PubMed Central identifier	PMC7070027
has PubMed identifier	32170151
schema:publication	Commun Biol
resource representing a document's body	covid:96d1423925b6930795b2ac9f2f8b48d4295f4364#body_text
is schema:about of	named entity 'DEEP' named entity 'analysis' named entity 'levels' named entity 'virus evolution' named entity 'STRATEGIES' named entity 'DIFFERENT' covid:arg/96d1423925b6930795b2ac9f2f8b48d4295f4364 named entity 'USE OF' named entity 'SPLICING' named entity 'CODE' named entity 'VIRUS' named entity 'PIPELINE' named entity 'ITS' named entity 'BIOINFORMATICS ANALYSIS' named entity 'OPEN READING FRAME' named entity '27S' named entity 'REVEALED' named entity 'LENGTHS' named entity 'COMPLEX' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'HAVE' named entity 'ADENOVIRUS' named entity 'PREVIOUSLY' named entity 'CODON USAGE' named entity 'DRIVES' named entity 'TRANSCRIPTOME' named entity 'INITIATING CODON' named entity 'INFECTION' named entity 'DENSITIES' named entity 'QUALITATIVE' named entity 'PLASTICITY' named entity 'VIRUS' named entity 'HUMAN ADENOVIRUS TYPE 5' named entity 'EVOLUTION' named entity 'LEVEL' named entity 'ALTERNATIVE SPLICING' named entity 'RENDERING' named entity 'SHORT' named entity 'VIRAL GENOME' named entity 'TEND' named entity 'COMPLEXITY' named entity 'SPLICED' named entity 'GENETIC' named entity 'LEVELS' named entity 'VIRAL' named entity 'SECONDARY' named entity 'HIGH' named entity 'PROGRESSES' named entity 'GENOMES' named entity 'PROBLEMATIC' named entity 'UNDERSTANDING' named entity 'GENE' named entity 'POLYADENYLATION' named entity 'APPROACHES' named entity 'RNA SEQUENCING' named entity 'USED' named entity 'MULTIPLE' named entity 'SHORTEN' named entity 'TRANSCRIPTS' named entity 'ACROSS' named entity 'RECORDED' named entity 'CENTRIC' named entity 'ENABLES' named entity 'POTENTIAL' named entity 'PROTEIN' named entity 'TRANSCRIPTION' named entity 'STUDY' named entity 'DEVELOPMENT' named entity 'LOW' named entity 'LONG' named entity 'DIRECT' named entity 'QUANTITATIVE' named entity 'RNA-SEQ ' named entity 'SPLICING' named entity 'PROVIDED' named entity 'PATTERNS' named entity 'READ'

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