About: Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

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About: Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine
Creator	Bogaert, Debby Sanders, Elisabeth Arp, Kayleigh Holloway, Mark Mitsi, Elena Nikolaou, Elissavet Pojar, Sherin Rylance, Jamie Carniel, Beatriz Chu, J De Steenhuijsen Piters, Wouter Ferreira, Daniela German, Esther Jochems, Simon Ling, Mei
Source	Medline; PMC
abstract	Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at baseline and post-LAIV influenza replication are detected in the low-density carriers. Also, we detected the fewest microbiota perturbations and mucosal cytokine responses in the low-density carriers compared to non-carriers or high-density carriers. These results indicate that the complete respiratory ecosystem affects pneumococcal behaviour following challenge, with low-density carriage representing the most stable ecological state.
has issue date	2019-07-05(xsd:dateTime)
bibo:doi	10.1038/s41467-019-10814-9
bibo:pmid	31278315
has license	cc-by
sha1sum (hex)	96ec828983678df332879221419bed8196b6b85f
schema:url	https://doi.org/10.1038/s41467-019-10814-9
resource representing a document's title	Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine
has PubMed Central identifier	PMC6611866
has PubMed identifier	31278315
schema:publication	Nat Commun
resource representing a document's body	covid:96ec828983678df332879221419bed8196b6b85f#body_text
is schema:about of	named entity 'INFLUENZA VACCINE' named entity 'Pneumococcal' named entity 'immunity' named entity 'carriage' named entity 'carriage' named entity 'replication' named entity 'involved' named entity 'LIVE' named entity 'ECOLOGICAL' named entity 'LOCAL' named entity 'RATES' named entity 'HIGH-DENSITY' named entity 'ATTENUATED' named entity 'EXPERIMENTAL' named entity 'ACQUISITION' named entity 'CO-INFECTIONS' named entity 'CYTOKINE ' named entity 'ADMINISTRATION' named entity 'STABLE' named entity 'ECOSYSTEM' named entity 'FOLLOWING' named entity 'REPLICATION' named entity 'PNEUMOCOCCAL' named entity 'CORYNEBACTERIUM' named entity 'LIVE' named entity 'INFLUENZA' named entity 'INDEPENDENT OF' named entity 'INFLUENZA VACCINE' named entity 'DETECTED' named entity 'RESULTS' named entity 'MUCOSAL IMMUNITY' named entity 'RESPIRATORY' named entity 'ASSOCIATED WITH' named entity 'MODEL' named entity 'CONSECUTIVE' named entity 'S. PNEUMONIAE' named entity 'MICROBIOTA' named entity 'CONTEXT' named entity 'MUCOSAL' named entity 'MAIN' named entity 'INVOLVED' named entity 'HERE' named entity 'LOW' named entity 'CARRIER' named entity 'PNEUMONIA' named entity 'BEHAVIOUR' named entity 'COLONIZATION' named entity 'REPORT' named entity 'DENSITY' named entity 'BASELINE' named entity 'NATURAL' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'ATTENUATED' named entity 'THESE' named entity 'COMPARED' named entity 'VIRAL' named entity 'HIGH' named entity 'RESPONSES' named entity 'LOWEST' named entity 'STATE' named entity 'HEALTHY ADULT' named entity 'INTERACTIONS' named entity 'DENSE' named entity 'NASAL' named entity 'CO-INFECTION' named entity 'LAIV' named entity 'CHALLENGE'

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