About: Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis

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About: Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis
Creator	Anuj, S Coulter, C Harbour, C Hargreaves, M Ristovski, Z Nissen, M Sloots, T Bell, S Fennelly, K France, M Kidd, T O'rourke, P Rose, B Wainwright, C
Source	Medline; PMC
abstract	BACKGROUND: Pseudomonas aeruginosa is the most common bacterial pathogen in patients with cystic fibrosis (CF). Current infection control guidelines aim to prevent transmission via contact and respiratory droplet routes and do not consider the possibility of airborne transmission. It was hypothesised that subjects with CF produce viable respirable bacterial aerosols with coughing. METHODS: A cross-sectional study was undertaken of 15 children and 13 adults with CF, 26 chronically infected with P aeruginosa. A cough aerosol sampling system enabled fractioning of respiratory particles of different sizes and culture of viable Gram-negative non-fermentative bacteria. Cough aerosols were collected during 5 min of voluntary coughing and during a sputum induction procedure when tolerated. Standardised quantitative culture and genotyping techniques were used. RESULTS: P aeruginosa was isolated in cough aerosols of 25 subjects (89%), 22 of whom produced sputum samples. P aeruginosa from sputum and paired cough aerosols were indistinguishable by molecular typing. In four cases the same genotype was isolated from ambient room air. Approximately 70% of viable aerosols collected during voluntary coughing were of particles ⩽3.3 μm aerodynamic diameter. P aeruginosa, Burkholderia cenocepacia, Stenotrophomonas maltophilia and Achromobacter xylosoxidans were cultivated from respiratory particles in this size range. Positive room air samples were associated with high total counts in cough aerosols (p = 0.003). The magnitude of cough aerosols was associated with higher forced expiratory volume in 1 s (r = 0.45, p = 0.02) and higher quantitative sputum culture results (r = 0.58, p = 0.008). CONCLUSION: During coughing, patients with CF produce viable aerosols of P aeruginosa and other Gram-negative bacteria of respirable size range, suggesting the potential for airborne transmission.
has issue date	2009-07-01(xsd:dateTime)
bibo:doi	10.1136/thx.2008.112466
bibo:pmid	19574243
has license	cc-by
sha1sum (hex)	9721af1b88d60abbff468d841941f85a13731861
schema:url	https://doi.org/10.1136/thx.2008.112466
resource representing a document's title	Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis
has PubMed Central identifier	PMC2764123
has PubMed identifier	19574243
schema:publication	Thorax
resource representing a document's body	covid:9721af1b88d60abbff468d841941f85a13731861#body_text
is schema:about of	named entity 'BACTERIA ' named entity 'tolerated' named entity 'Methods' named entity 'viable' named entity 'Conclusion' named entity 'culture' named entity 'patients' named entity 'GRAM-NEGATIVE BACTERIA' covid:arg/9721af1b88d60abbff468d841941f85a13731861 named entity 'INFECTED' named entity 'PARTICLES' named entity 'CULTURE' named entity 'CHRONICALLY' named entity 'CHILDREN' named entity 'BACTERIAL PATHOGEN' named entity 'SUBJECTS' named entity 'ENABLED' named entity 'PSEUDOMONAS AERUGINOSA' named entity 'SAMPLES' named entity 'ADULTS' named entity 'COUGHING' named entity '0.02' named entity 'INFECTION CONTROL' named entity 'COLLECTED' named entity 'SIZE RANGE' named entity 'BACTERIAL' named entity 'DIFFERENT' named entity '283' named entity 'FORCED EXPIRATORY VOLUME' named entity 'PATIENTS' named entity '008' named entity 'METHODS' named entity 'TO PREVENT' named entity '3 MM' named entity 'BURKHOLDERIA CENOCEPACIA' named entity 'GRAM-NEGATIVE BACTERIA' named entity 'STENOTROPHOMONAS MALTOPHILIA' named entity 'SYSTEM' named entity 'GENOTYPING TECHNIQUES' named entity 'ROUTES' named entity 'INDUCTION PROCEDURE' named entity 'VOLUNTARY' named entity 'MOLECULAR TYPING' named entity '0.58' named entity 'TRANSMISSION' named entity 'AIRBORNE TRANSMISSION' named entity 'SAMPLING' named entity 'PRODUCE' named entity 'AEROSOL' named entity '0.003' named entity 'AMBIENT' named entity 'SPUTUM' named entity 'RESULTS' named entity 'HIGH' named entity 'ASSOCIATED WITH' named entity 'CASES' named entity 'GUIDELINES ' named entity 'COMMON' named entity 'COUGH' named entity 'TOTAL' named entity 'SPUTUM CULTURE' named entity 'ACHROMOBACTER XYLOSOXIDANS' named entity 'COUGH' named entity 'PSEUDOMONAS AERUGINOSA' named entity 'BACKGROUND' named entity 'AEROSOLS' named entity 'PATIENTS' named entity 'QUANTITATIVE'

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