About: Postmortem diagnosis of cytomegalovirus and accompanying other infection agents by real-time PCR in cases of sudden unexpected death in infancy (SUDI)

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About: Postmortem diagnosis of cytomegalovirus and accompanying other infection agents by real-time PCR in cases of sudden unexpected death in infancy (SUDI) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Postmortem diagnosis of cytomegalovirus and accompanying other infection agents by real-time PCR in cases of sudden unexpected death in infancy (SUDI)
Creator	Ziyade, Nihan Akcay, Arzu Das, Taner Elgormus, Neval Karayel, Ferah Koc, Sermet Ozgun, Ayse Yagmur, Gulhan Yildirim, Muzaffer Feyzi Sahin, M
Source	Elsevier; Medline; PMC
abstract	As an opportunistic pathogen with high mortality rates, Cytomegalovirus (CMV) may lead to fatal disseminated CMV infection of the premature and newborn; thus necessitating the demonstration of CMV-DNA with clinical history and/or histopathological findings of CMV infection and defining other bacterial and viral infection agents with real-time polymerase chain reaction (RT-PCR) in udden unexpected death in infancy (SUDI) cases as we aimed in this study. 314 (144 female, 170 male) SUDI cases were prospectively investigated from January 2013 to January 2015 in Istanbul Forensic Medicine Institution. The study includes 87 tissue samples of 39 cases for post-mortem histopathological examination of interstitial pneumonia, myocarditis, meningitis, encephalitis, hepatitis, colitis or tubulointerstitial nephritis and/or accompanying chronic sialadenitis. CMV-DNA was found positive in 35 (40.2%) salivary gland, 19 (21.8%) lung, 1 (1.1%) tonsil, and 1 (1.1%) brain tissues. CMV sialadenitis and/or CMV pneumonia associated with other viral and/or bacterial agents were detected in 23 (60%) of 39 infant cases. The demonstration of CMV-DNA would significantly clarify the cause of death and collection of epidemiological data in SUDI cases with clinical history and histopathological findings of CMV infection accompanying chronic CMV sialadenitis. Furthermore, CMV suppresses the immune system, and may predispose to other bacterial and/or viral infections in these cases. Post-mortem molecular investigations are useful in explaining cause of death in SUDI with a suspicion of infection in forensic autopsies.
has issue date	2015-11-23(xsd:dateTime)
bibo:doi	10.1016/j.jflm.2015.11.008
bibo:pmid	26694873
has license	no-cc
sha1sum (hex)	9729f7d3bc0199e03edea694804c99b25d287413
schema:url	https://doi.org/10.1016/j.jflm.2015.11.008
resource representing a document's title	Postmortem diagnosis of cytomegalovirus and accompanying other infection agents by real-time PCR in cases of sudden unexpected death in infancy (SUDI)
has PubMed Central identifier	PMC7118459
has PubMed identifier	26694873
schema:publication	J Forensic Leg Med
resource representing a document's body	covid:9729f7d3bc0199e03edea694804c99b25d287413#body_text
is schema:about of	named entity 'investigated' named entity 'bacterial' named entity 'infection' named entity 'histopathological' named entity 'agents' named entity 'infection' named entity 'ACCOMPANYING' named entity 'CYTOMEGALOVIRUS' named entity 'SAMPLES' named entity 'DEATH IN INFANCY' named entity 'INTERSTITIAL PNEUMONIA' named entity 'TISSUE' named entity 'TUBULOINTERSTITIAL NEPHRITIS' named entity 'INCLUDES' named entity 'CYTOMEGALOVIRUS' named entity 'DEMONSTRATION' named entity 'UNEXPECTED DEATH' named entity 'BACTERIAL' named entity 'DEFINING' named entity 'PCR' named entity 'CHRONIC SIALADENITIS' named entity 'PREMATURE' named entity 'INSTITUTION' named entity 'DIAGNOSIS' named entity 'UNEXPECTED DEATH' named entity 'FATAL' named entity 'DNA' named entity 'HIGH' named entity 'POSTMORTEM' named entity 'OTHER INFECTION' named entity 'SUDDEN' named entity 'HEPATITIS' named entity 'POSTMORTEM' named entity '170' named entity 'CASES' named entity 'CLINICAL HISTORY' named entity 'OPPORTUNISTIC PATHOGEN' named entity 'FEMALE' named entity 'DEATH IN INFANCY' named entity 'REAL-TIME PCR ' named entity 'CASES' named entity 'MYOCARDITIS' named entity 'COLITIS' named entity 'MENINGITIS' named entity 'LEAD' named entity 'ISTANBUL' named entity 'CMV' named entity 'MORTALITY RATES' named entity 'STUDY' named entity 'ENCEPHALITIS' named entity 'FINDINGS' named entity '2015' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'INVESTIGATED' named entity 'CMV INFECTION' named entity 'EXAMINATION' named entity 'JANUARY' named entity 'DISSEMINATED' named entity 'HISTOPATHOLOGICAL' named entity 'VIRAL INFECTION' named entity 'MALE' named entity 'ACCOMPANYING' named entity 'FORENSIC MEDICINE' named entity 'NEWBORN' covid:arg/9729f7d3bc0199e03edea694804c99b25d287413 named entity 'CMV' named entity 'mortality rates' named entity 'premature' named entity 'interstitial pneumonia' named entity 'histopathological examination' named entity 'defining' named entity 'prospectively'

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