About: Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line

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About: Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line
Creator	Dewhurst, Stephen Kim, Baek Chugh, Pauline Fan, Shongshan Maggirwar, Sanjay Planelles, Vicente
Source	Elsevier; Medline; PMC
abstract	Abstract The interaction of human immunodeficiency virus type 1 (HIV-1) with CD4+ T lymphocytes is well studied and typically results in virally induced cytolysis. In contrast, relatively little is known concerning the interplay between HIV-1 and microglia. Recent findings suggest that, counter-intuitively, HIV-1 infection may extend the lifespan of microglia. We developed a novel cell line model system to confirm and mechanistically study this phenomenon. We found that transduction of a human microglial cell line with an HIV-1 vector results in a powerful cytoprotective effect following apoptotic challenge. This effect was reproduced by ectopic expression of a single virus-encoded protein, Tat. Subsequent studies showed that the pro-survival effects of intracellular Tat could be attributed to activation of the PI-3-kinase (PI3K)/Akt pathway in the microglial cell line. Furthermore, we found that expression of Tat led to decreased expression of PTEN, a negative regulator of the PI-3-K pathway. Consistent with this, decreased p53 activity and increased E2F activity were observed. Based on these findings, a model of possible regulatory circuits that intracellular Tat and HIV-1 infection engage during the cytoprotective event in microglia has been suggested. We propose that the expression of Tat may enable HIV-1 infected microglia to survive throughout the course of infection, leading to persistent HIV-1 production and infection in the central nervous system.
has issue date	2007-02-09(xsd:dateTime)
bibo:doi	10.1016/j.jmb.2006.11.011
bibo:pmid	17157319
has license	els-covid
sha1sum (hex)	973b709be1f105a101100621ae88d48176de58d0
schema:url	https://doi.org/10.1016/j.jmb.2006.11.011
resource representing a document's title	Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line
has PubMed Central identifier	PMC7127718
has PubMed identifier	17157319
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:973b709be1f105a101100621ae88d48176de58d0#body_text
is schema:about of	named entity 'INFECTION' named entity 'Protein' named entity 'Infection' named entity 'MICROGLIAL CELL LINE' named entity 'EXERT' named entity 'VIRAL' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'HUMAN' named entity 'PROTEIN ' named entity 'EFFECT' named entity 'TAT PROTEIN' named entity 'PRO-SURVIVAL' named entity 'INTRACELLULAR' named entity 'Tat' named entity 'Infection' named entity 'Viral' named entity 'human papilloma virus' named entity 'HIV-1' named entity 'HIV-1' named entity 'Akt' named entity 'LPS' named entity 'Mdm2' named entity 'Akt' named entity 'cell death' named entity 'neurotoxic' named entity 'Tat protein' named entity 'recombinant' named entity 'vector' named entity 'macrophage' named entity 'FKHR' named entity 'macrophage' named entity 'red cells' named entity 'amino acid' named entity 'Lysates' named entity 'HIV-1 infection' named entity 'vector' named entity 'cell cycle' named entity 'HIV-1' named entity 'virus' named entity 'Lipofectamine' named entity 'IgG' named entity 'nitric oxide' named entity 'incubation' named entity 'nitric oxide' named entity 'Pseudotyped' named entity 'viral proteins' named entity 'Akt' named entity 'vector' named entity 'cell line' named entity 'microglial cell' named entity 'transfected' named entity 'transfected' named entity 'LPS' named entity 'GFP' named entity 'microglial cells' named entity 'neurons' named entity 'DNA synthesis' named entity 'wild-type' named entity 'dominant negative' named entity 'cell division' named entity 'dead cells' named entity 'Akt' named entity 'PIP2' named entity 'transfected' named entity 'w/v' named entity 'Cip1' named entity 'p53' named entity 'Invitrogen' named entity 'HIV-1' named entity 'apoptotic' named entity 'trypan blue' named entity 'SNP' named entity 'microglia' named entity 'HIV-1 infection' named entity 'TRAIL' named entity 'pseudotyped'

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