About: Biogenesis and architecture of arterivirus replication organelles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biogenesis and architecture of arterivirus replication organelles
Creator	Kikkert, Marjolein Bárcena, Montserrat Oudshoorn, Diede Snijder, Eric Koster, Abraham Van Der Hoeven, Barbara
Source	Elsevier; Medline; PMC
abstract	Abstract All eukaryotic positive-stranded RNA (+RNA) viruses appropriate host cell membranes and transform them into replication organelles, specialized micro-environments that are thought to support viral RNA synthesis. Arteriviruses (order Nidovirales) belong to the subset of +RNA viruses that induce double-membrane vesicles (DMVs), similar to the structures induced by e.g. coronaviruses, picornaviruses and hepatitis C virus. In the last years, electron tomography has revealed substantial differences between the structures induced by these different virus groups. Arterivirus-induced DMVs appear to be closed compartments that are continuous with endoplasmic reticulum membranes, thus forming an extensive reticulovesicular network (RVN) of intriguing complexity. This RVN is remarkably similar to that described for the distantly related coronaviruses (also order Nidovirales) and sets them apart from other DMV-inducing viruses analysed to date. We review here the current knowledge and open questions on arterivirus replication organelles and discuss them in the light of the latest studies on other DMV-inducing viruses, particularly coronaviruses. Using the equine arteritis virus (EAV) model system and electron tomography, we present new data regarding the biogenesis of arterivirus-induced DMVs and uncover numerous putative intermediates in DMV formation. We generated cell lines that can be induced to express specific EAV replicase proteins and showed that DMVs induced by the transmembrane proteins nsp2 and nsp3 form an RVN and are comparable in topology and architecture to those formed during viral infection. Co-expression of the third EAV transmembrane protein (nsp5), expressed as part of a self-cleaving polypeptide that mimics viral polyprotein processing in infected cells, led to the formation of DMVs whose size was more homogenous and closer to what is observed upon EAV infection, suggesting a regulatory role for nsp5 in modulating membrane curvature and DMV formation.
has issue date	2016-07-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2016.04.001
bibo:pmid	27071852
has license	els-covid
sha1sum (hex)	9749435126275cc8b4c6d69d8eba0cbc796406b4
schema:url	https://doi.org/10.1016/j.virusres.2016.04.001
resource representing a document's title	Biogenesis and architecture of arterivirus replication organelles
has PubMed Central identifier	PMC7111217
has PubMed identifier	27071852
schema:publication	Virus Research
resource representing a document's body	covid:9749435126275cc8b4c6d69d8eba0cbc796406b4#body_text
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