About: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection

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About: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection
Creator	Green, Richard Sova, Pavel Chang, Stewart Katze, Michael Palermo, Robert Thomas, Matthew Prasad, Vinayaka
Source	Medline; PMC
abstract	HIV infection of CD4(+) T cells induces a range of host transcriptional changes in mRNAs as well as microRNAs that may coordinate changes in mRNAs. To survey these dynamic changes, we applied next-generation sequencing, analyzing the small RNA fraction of HIV-infected cells at 5, 12, and 24 h postinfection (RNA-Seq). These time points afforded a view of the transcriptomic changes occurring both before and during viral replication. In the resulting small RNA-Seq data set, we detected a phased pattern of microRNA expression. Largely distinct sets of microRNAs were found to be suppressed at 5 and 12 h postinfection, and both sets of changes rebounded later in infection. A larger set of microRNA changes was observed at 24 h postinfection. When integrated with mRNA expression data, the small RNA-Seq data indicated a role for microRNAs in transcriptional regulation, T cell activation, and cell cycle during HIV infection. As a unique benefit of next-generation sequencing, we also detected candidate novel host microRNAs differentially expressed during infection, including one whose downregulation at 24 h postinfection may allow full replication of HIV to proceed. Collectively, our data provide a uniquely comprehensive view of the changes in host microRNAs induced by HIV during cellular infection.
has issue date	2013-02-05(xsd:dateTime)
bibo:doi	10.1128/mbio.00549-12
bibo:pmid	23386435
has license	cc-by-nc-sa
sha1sum (hex)	97a1bf0cca7e6b48364be99814a22a5440c521f3
schema:url	https://doi.org/10.1128/mbio.00549-12
resource representing a document's title	Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection
has PubMed Central identifier	PMC3560529
has PubMed identifier	23386435
schema:publication	mBio
resource representing a document's body	covid:97a1bf0cca7e6b48364be99814a22a5440c521f3#body_text
is schema:about of	named entity 'INFECTED' named entity 'PATTERNS' named entity 'CHANGES' named entity 'EXPRESSED' named entity 'HIV' named entity 'LATER' named entity 'MICRORNA' named entity 'CELLULAR' named entity 'FOUND' named entity 'RESULTING' named entity 'ROLE' named entity 'INFECTION' named entity 'PROVIDE' named entity 'TRANSCRIPTIONAL' named entity 'DOWNREGULATION' named entity 'VIEW' named entity 'T CELLS' named entity 'VIRAL REPLICATION' named entity 'TRANSCRIPTIONAL REGULATION' named entity 'RNA-SEQ DATA' named entity 'microRNA' named entity 'viral replication' named entity 'infection' named entity 'survey' named entity 'infection' named entity 'expression' named entity 'expressed' named entity 'HIV' named entity 'Small RNAs' named entity 'MRNA EXPRESSION' named entity 'NEXT-GENERATION SEQUENCING' named entity 'MICRORNA EXPRESSION' named entity 'SMALL' named entity 'HIV' covid:arg/97a1bf0cca7e6b48364be99814a22a5440c521f3 named entity 'MICRORNAS' named entity 'NOVEL' named entity 'INTEGRATED' named entity 'SMALL RNA-SEQ' named entity 'LARGER' named entity 'DATA SET' named entity 'COMPREHENSIVE' named entity 'INCLUDING' named entity 'RANGE' named entity 'DETECTED' named entity 'RNAS' named entity 'PHASED' named entity 'EXPRESSED' named entity 'CELLS' named entity 'INFECTION' named entity 'CANDIDATE' named entity 'DYNAMIC' named entity 'PHASED' named entity 'SET' named entity 'REPLICATION' named entity 'LARGELY' named entity 'OBSERVED' named entity 'SURVEY' named entity 'INDICATED' named entity 'HIV INFECTION' named entity 'THESE' named entity 'MICRORNAS' named entity 'T CELL ACTIVATION' named entity 'BENEFIT' named entity 'FRACTION OF' named entity 'INDUCED' named entity 'MICRORNA EXPRESSION' named entity 'NEXT-GENERATION SEQUENCING' named entity 'OUR' named entity 'SMALL RNA' named entity 'POINTS' named entity 'CANDIDATE' named entity 'CELLS' named entity 'SUPPRESSED' named entity 'HOST'

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