About: Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches

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About: Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches
Creator	Wang, Jialu Yang, Qian Huang, Lulu Yuan, Chen Zhang, En
Source	PMC
abstract	BACKGROUND: Peyer’s patches (PPs) can be considered as the immune site of the intestine. Within PPs, Dendritic cells (DCs) can uptake antigens from the gut lumen by extending dendrites into epithelium, and process it and then present to lymphocytes, which effectively antigen produces an immune response. Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea (PED), an acute and highly contagious enteric viral disease. The interaction between inactivated porcine epidemic diarrhea virus and porcine monocyte-derived dendritic cells (Mo-DCs) has been reported. However, little is known about the interaction between inactivated PEDV and DCs in porcine PPs. RESULTS: In this study, for the first time we investigated the role of DCs in porcine PPs after oral administration inactivated PEDV. Firstly, a method to isolate DCs from porcine PPs was established, in which the purity of SWC3a(+)/MHC-II(+) DCs was more than 90%. Our findings clearly indicate that DCs in porcine PPs after oral administration of inactivated PEDV not only stimulated the proliferation of allogeneic lymphocytes, but also secreted cytokines (IL-1, IL-4). Furthermore, the number of DCs and IgA(+) cells in porcine intestinal mucosal significantly increased and the levels of anti-PEDV specific IgG antibody in the serum and SIgA antibody in the feces increased after oral administration inactivated PEDV. CONCLUSIONS: Our findings indicate that oral administration of inactivated PEDV activate DCs in porcine Peyer’s patches and inactivated PEDV may be a useful and safe vaccine to trigger adaptive immunity.
has issue date	2018-08-16(xsd:dateTime)
bibo:doi	10.1186/s12917-018-1568-z
bibo:pmid	30115049
has license	cc-by
sha1sum (hex)	97b03849d178cb08d39be44ebab0a2aa41b6a4d3
schema:url	https://doi.org/10.1186/s12917-018-1568-z
resource representing a document's title	Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches
has PubMed Central identifier	PMC6097195
has PubMed identifier	30115049
schema:publication	BMC Vet Res
resource representing a document's body	covid:97b03849d178cb08d39be44ebab0a2aa41b6a4d3#body_text
is schema:about of	named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'DCS' named entity 'The' named entity 'immune' named entity 'intestine' named entity 'ABOUT' named entity 'EXTENDING' named entity 'BACKGROUND' named entity 'IMMUNE' named entity '27S' named entity 'PROCESS' named entity 'ENTERIC' named entity 'DENDRITIC CELLS' named entity 'LITTLE' named entity 'ANTIGENS' named entity 'VIRAL DISEASE' named entity 'LYMPHOCYTES' named entity 'INACTIVATED' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PORCINE' named entity 'KNOWN' named entity 'INTESTINE' named entity 'GUT LUMEN' named entity 'ANTIGEN' named entity 'INTERACTION' named entity 'DCS' named entity 'PORCINE' named entity 'ACTIVATE' named entity 'CONSIDERED' named entity 'THE GUT' named entity 'PPS' named entity 'REPORTED' named entity 'INACTIVATED' named entity 'PORCINE EPIDEMIC DIARRHEA' named entity 'EPITHELIUM' named entity 'ORAL ADMINISTRATION' named entity 'UPTAKE' named entity 'PRESENT' named entity 'HIGHLY' named entity 'IMMUNE RESPONSE' named entity '27S' named entity 'CAUSATIVE AGENT' named entity 'ACUTE' named entity 'DENDRITES' named entity 'SITE OF' covid:arg/97b03849d178cb08d39be44ebab0a2aa41b6a4d3 named entity 'interaction' named entity 'DCs' named entity 'porcine' named entity 'porcine epidemic diarrhea virus' named entity 'antigens' named entity 'lumen' named entity 'porcine' named entity 'Peyer's patches' named entity 'causative agent' named entity 'digestive tract' named entity '37°C' named entity 'IgA' named entity 'FACS' named entity 'PEDV' named entity 'PEDV' named entity 'adaptive immune responses' named entity 'porcine' named entity 'enzyme-linked immunosorbent assay' named entity 'plasmacytoid DCs' named entity 'PEDV' named entity 'tissue sections' named entity 'allogeneic' named entity 'epidemic' named entity 'DCs' named entity 'DCs' named entity 'China' named entity 'interfollicular' named entity 'sulfuric acid' named entity 'Jiangsu' named entity 'porcine' named entity 'cytokines'

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