About: Recent advances in siRNA delivery mediated by lipid-based nanoparticles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Creator	Asai, Tomohiro Koide, Hiroyuki Yonezawa, Sei
Source	PMC
abstract	Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the treatment of broad-spectrum intractable diseases. However, its unfavorable properties such as easy degradation in the blood and negative-charge density are still a formidable barrier for clinical use. For disruption of this barrier, siRNA delivery technology has been significantly advanced in the past two decades. The approval of Patisiran (ONPATTRO™) for the treatment of transthyretin-mediated amyloidosis, the first approved siRNA drug, is a most important milestone. Since lipid-based nanoparticles (LNPs) are used in Patisiran, LNP-based siRNA delivery is now of significant interest for the development of the next siRNA formulation. In this review, we describe the design of LNPs for the improvement of siRNA properties, bioavailability, and pharmacokinetics. Recently, a number of siRNA-encapsulated LNPs were reported for the treatment of intractable diseases such as cancer, viral infection, inflammatory neurological disorder, and genetic diseases. We believe that these contributions address and will promote the development of an effective LNP-based siRNA delivery system and siRNA formulation.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1016/j.addr.2020.07.022
has license	no-cc
sha1sum (hex)	97bc4a9a53cfbaa2f89fc0fb1ddeea5c17e22588
schema:url	https://doi.org/10.1016/j.addr.2020.07.022
resource representing a document's title	Recent advances in siRNA delivery mediated by lipid-based nanoparticles
has PubMed Central identifier	PMC7406478
schema:publication	Adv Drug Deliv Rev
resource representing a document's body	covid:97bc4a9a53cfbaa2f89fc0fb1ddeea5c17e22588#body_text
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