About: HMGXB4 Targets Sleeping Beauty Transposition to Vertebrate Germinal Stem Cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: HMGXB4 Targets Sleeping Beauty Transposition to Vertebrate Germinal Stem Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	HMGXB4 Targets Sleeping Beauty Transposition to Vertebrate Germinal Stem Cells
Creator	Singh, Manvendra Becker, Mareike Cseresznyés, Zoltán Dawid, Grzela Devaraj, Anantharam Ivics, Zoltán Izsvák, Zsuzsanna Narayanavari, Suneel Raskó, Tamás Schorn, Andrea Selbach, Matthias Walisko, Oliver Wang, Jiaxuan Wang, Jichang Yong, Guo
source	BioRxiv
abstract	Transposons are parasitic genetic elements that frequently hijack key cellular processes of the host. HMGXB4 is a Wnt signalling-associated HMG-box protein, previously identified as a transcriptional regulating host factor of Sleeping Beauty (SB) transposition. Here, we establish that HMGXB4 is highly expressed from the zygote stage, and declines after transcriptional genome activation. Nevertheless, HMGXB4 is activated by its own promoter at 4-cell stage, responding to the parental-to-zygotic transition, marks stemness, and maintains its expression during germ cell specification. The HMGXB4 promoter is located at an active chromatin domain boundary. As a vertebrate-specific modulator of SETD1A and NuRF complexes, HMGXB4 links histone H3K4 methyltransferase- and ATP-dependent nucleosome remodelling activities. The expression of HMGXB4 is regulated by the KRAB-ZNF/TRIM28 epigenetic repression machinery. A post-transcriptional modification by SUMOylation diminishes its transcriptional activator function and regulates its nucleolar trafficking. Collectively, HMGXB4 positions SB transposition into an elaborate stem cell-specific transcriptional regulatory mechanism that is active during early embryogenesis and germline development, thereby potentiating heritable transposon insertions in the germline.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1101/2020.06.15.145656
has license	biorxiv
sha1sum (hex)	98093090d42010af39dde20914d4a9c63ed1ccc6
schema:url	https://doi.org/10.1101/2020.06.15.145656
resource representing a document's title	HMGXB4 Targets Sleeping Beauty Transposition to Vertebrate Germinal Stem Cells
schema:publication	bioRxiv
resource representing a document's body	covid:98093090d42010af39dde20914d4a9c63ed1ccc6#body_text
is schema:about of	named entity 'parasitic' named entity 'Stem Cells' named entity 'Transposition' named entity 'frequently' named entity 'half-life' named entity 'histone methyltransferase' named entity 'SUMO1' named entity 'spermatogonial' named entity 'genetic elements' named entity 'Transposons' named entity 'Vertebrate' named entity 'SUMO' named entity 'CUT&RUN' named entity 'transactivation' named entity 'life cycle' named entity 'somatic' named entity 'methylate' named entity 'nucleolus' named entity 'cut and paste' named entity 'nucleolus' named entity 'protein' named entity 'transposition' named entity 'heritable' named entity 'retrotransposons' named entity 'transfected' named entity 'HeLa' named entity 'nucleolus' named entity 'nucleosome' named entity 'nucleosome' named entity 'splicing' named entity 'spermatogonial stem cell' named entity 'NuRF' named entity 'POU5F1' named entity 'NuRF' named entity 'phylogenetically conserved' named entity 'stemness' named entity 'Y2H' named entity 'transposition' named entity 'androgen receptor' named entity 'Western blotting' named entity 'SUMOylation' named entity 'SUMO1' named entity 'SUMO1' named entity 'NotI' named entity 'transposable elements' named entity 'CTCF' named entity 'vertebrate' named entity 'MED1' named entity 'p-value' named entity 'viruses' named entity 'male germ cells' named entity 'SUMO' named entity 'proteome' named entity 'histone demethylase' named entity 'transcriptome' named entity 'nuclei' named entity 'mass spectrometry' named entity 'ligase' named entity 'Transcriptional control' named entity 'embryonic stem cells' named entity 'TSS' named entity 'locus' named entity 'transposable elements' named entity 'germinal vesicle' named entity 'enzymatic activity' named entity 'SUMOylation' named entity 'organism' named entity 'stem cells' named entity 'H3K4me3' named entity 'transposase'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software