About: Detection of new biallelic polymorphisms in the human MxA gene

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About: Detection of new biallelic polymorphisms in the human MxA gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of new biallelic polymorphisms in the human MxA gene
Creator	Desmecht, Daniel Farnir, Frédéric Michaux, Charles Duc, Thi Tran, Tam
Source	Medline; PMC
abstract	The interferon-inducible human MxA protein plays an important role in innate defense against an array of viruses. One might expect allelic diversity at the MxA locus to influence the timing and magnitude of its expression or even the range of viruses whose biological cycle is inhibited by the encoded product. Here we have collected 267 samples of genomic DNA from three distinct populations (European, Asian, and African) and have systematically sequenced the promoter of the MxA gene and its 17 exons in order to inventory its allelic variants. Eighteen single-nucleotide polymorphisms were detected, four of which had never been identified before. Two of these, located in the promoter (at positions −309 and −101 respectively), might affect the MxA expression pattern. The other two result in substitutions (Gly255Glu and Val268Met) in the protein’s N-terminal region that might directly affect its antiviral function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11033-012-1708-7) contains supplementary material, which is available to authorized users.
has issue date	2012-06-20(xsd:dateTime)
bibo:doi	10.1007/s11033-012-1708-7
bibo:pmid	22714910
has license	no-cc
sha1sum (hex)	987d54479a58f0aaf96f5a8751e51d2747ffd6e9
schema:url	https://doi.org/10.1007/s11033-012-1708-7
resource representing a document's title	Detection of new biallelic polymorphisms in the human MxA gene
has PubMed Central identifier	PMC7088644
has PubMed identifier	22714910
schema:publication	Mol Biol Rep
resource representing a document's body	covid:987d54479a58f0aaf96f5a8751e51d2747ffd6e9#body_text
is schema:about of	named entity 'promoter' named entity 'MxA' named entity 'array' named entity 'biological' named entity 'located' named entity 'polymorphisms' named entity 'human' named entity 'DETECTION' named entity 'NEW' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISMS' named entity 'DIVERSITY' named entity 'EIGHTEEN' named entity 'VARIANTS' named entity 'DISTINCT' named entity 'MXA' named entity 'INDUCIBLE' named entity 'LOCATED IN' named entity '101' named entity '267' named entity 'FUNCTION' named entity 'HAVE' named entity 'VIRUSES' named entity '27S' named entity 'REGION' named entity 'DETECTED' named entity 'BIOLOGICAL CYCLE' named entity 'HERE' named entity 'AFRICAN' named entity 'EXONS' named entity 'RANGE' named entity 'MAGNITUDE' named entity 'PLAYS' named entity 'INTERFERON' named entity 'MXA' named entity 'HUMAN' named entity 'GENE' named entity 'DEFENSE' named entity 'EXPRESSION' named entity 'HUMAN' named entity 'POPULATIONS' named entity 'MXA PROTEIN' named entity 'COLLECTED' named entity 'EXPRESSION PATTERN' named entity 'ORDER' named entity 'PROTEIN' named entity 'IDENTIFIED' named entity 'THESE' named entity 'AFFECT' named entity 'ROLE' named entity 'POLYMORPHISMS' named entity 'NEVER' named entity 'ARRAY' named entity 'ENCODED' named entity 'PROTEIN ' named entity 'DIRECTLY' named entity 'PROMOTER' named entity 'INFLUENCE' named entity 'ASIAN' named entity 'TIMING' named entity 'SAMPLES' named entity 'N-TERMINAL ' named entity 'INHIBITED' named entity 'LOCUS' named entity 'INVENTORY' named entity 'ITS' named entity 'POSITIONS' named entity 'RESULT' named entity 'IMPORTANT' named entity 'GENE' named entity 'PRODUCT' named entity 'GENOMIC DNA' named entity 'ANTIVIRAL' named entity 'inventory' named entity 'range' named entity 'human' named entity 'viruses' named entity 'One'

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