About: Compactness of viral genomes: effect of disperse and localized random mutations

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Compactness of viral genomes: effect of disperse and localized random mutations
Creator	Micheletti, Cristian Božič, Anže Podgornik, Rudolf Tubiana, Luca
Source	PMC
abstract	Genomes of single-stranded RNA viruses have evolved to optimize several concurrent properties. One of them is the architecture of their genomic folds, which must not only feature precise structural elements at specific positions, but also allow for overall spatial compactness. The latter was shown to be disrupted by random synonymous mutations, a disruption which can consequently negatively affect genome encapsidation. In this study, we use three mutation schemes with different degrees of locality to mutate the genomes of phage MS2 and Brome Mosaic virus in order to understand the observed sensitivity of the global compactness of their folds. We find that mutating local stretches of their genomes’ sequence or structure is less disruptive to their compactness compared to inducing randomly-distributed mutations. Our findings are indicative of a mechanism for the conservation of compactness acting on a global scale of the genomes, and have several implications for understanding the interplay between local and global architecture of viral RNA genomes.
has issue date	2018-02-28(xsd:dateTime)
bibo:doi	10.1088/1361-648x/aaa7b0
bibo:pmid	29334364
has license	no-cc
sha1sum (hex)	988fda0345e21eff13cd4bc081664f7b9f3c103b
schema:url	https://doi.org/10.1088/1361-648x/aaa7b0
resource representing a document's title	Compactness of viral genomes: effect of disperse and localized random mutations
has PubMed Central identifier	PMC7104904
has PubMed identifier	29334364
schema:publication	J Phys Condens Matter
resource representing a document's body	covid:988fda0345e21eff13cd4bc081664f7b9f3c103b#body_text
is schema:about of	named entity 'affect' named entity 'order' named entity 'scale' named entity 'genomic' named entity 'mechanism' named entity 'degrees' named entity 'local' named entity 'compared' named entity 'genome' named entity 'compactness' named entity 'synonymous mutations' named entity 'optimize' named entity 'precise' named entity 'single-stranded RNA' named entity 'non-specific' named entity 'genomic sequences' named entity 'nucleotides' named entity 'genomes' named entity 'RNA' named entity 'nucleotides' named entity 'BMV' named entity 'RNA' named entity 'MS2' named entity 'MS2' named entity 'uniformly distributed' named entity 'RNA secondary structure' named entity 'BMV' named entity 'BMV' named entity 'RNA' named entity 'BMV' named entity 'ssRNA' named entity 'viral RNAs' named entity 'electrostatic' named entity 'synonymous mutations' named entity 'RNA' named entity 'secondary structure prediction' named entity 'mutation' named entity 'viral capsids' named entity 'stochastic' named entity 'MS2' named entity 'violin' named entity 'RNA' named entity 'nucleotide' named entity 'genomes' named entity 'BMV' named entity 'nucleotides' named entity 'mutation' named entity 'capsid' named entity 'BMV' named entity 'viruses' named entity 'osmotic pressure' named entity 'BMV' named entity 'MS2' named entity 'secondary structure' named entity 'probability' named entity 'coat proteins' named entity 'RNA' named entity 'synonymous mutations' named entity 'genomes' named entity 'RNA' named entity 'nucleotides' named entity 'icosahedral' named entity 'radius of gyration' named entity 'nucleotides' named entity 'ssRNA' named entity '2.1' named entity 'stochastic' named entity 'viral coat proteins' named entity 'persistence length' named entity 'probability' named entity 'random mutations' named entity 'nucleotides' named entity 'RNA' named entity 'genomes' named entity 'nucleotides' named entity 'genomic sequence' named entity 'Leviviridae' named entity 'entire genome'

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