About: Utility of homology models in the drug discovery process

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Utility of homology models in the drug discovery process
Creator	Hilgenfeld, Rolf Hillisch, Alexander Pineda, Luis
Source	Elsevier; Medline; PMC
abstract	Advances in bioinformatics and protein modeling algorithms, in addition to the enormous increase in experimental protein structure information, have aided in the generation of databases that comprise homology models of a significant portion of known genomic protein sequences. Currently, 3D structure information can be generated for up to 56% of all known proteins. However, there is considerable controversy concerning the real value of homology models for drug design. This review provides an overview of the latest developments in this area and includes selected examples of successful applications of the homology modeling technique to pharmaceutically relevant questions. In addition, the strengths and limitations of the application of homology models during all phases of the drug discovery process are discussed.
has issue date	2004-07-25(xsd:dateTime)
bibo:doi	10.1016/s1359-6446(04)03196-4
bibo:pmid	15279849
has license	no-cc
sha1sum (hex)	99156f16aa2efd7b6ccd284fbec65d5b1efc2968
schema:url	https://doi.org/10.1016/s1359-6446%2804%2903196-4
resource representing a document's title	Utility of homology models in the drug discovery process
has PubMed Central identifier	PMC7129151
has PubMed identifier	15279849
schema:publication	Drug Discov Today
resource representing a document's body	covid:99156f16aa2efd7b6ccd284fbec65d5b1efc2968#body_text
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