About: Comparison of Neurotization Versus Nerve Repair in an Animal Model of Chronically Denervated Muscle

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About: Comparison of Neurotization Versus Nerve Repair in an Animal Model of Chronically Denervated Muscle Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of Neurotization Versus Nerve Repair in an Animal Model of Chronically Denervated Muscle
Creator	Doty, Stephen Ehteshami, John Feinberg, Joseph Khazzam, Michael Swanson, Andrew Wolfe, Scott
Source	Elsevier; Medline; PMC
abstract	Purpose Reinnervation of chronically denervated muscle is clinically unpredictable and poorly understood. Current operative strategies include either direct nerve repair, nerve grafting, nerve transfer, or neurotization. The goal of this study is to compare muscle recovery using microneural repair versus neurotization in a rat model of chronic denervation. Methods Fifty-eight Sprague-Dawley rats had surgical denervation of the tibialis anterior muscle by transecting the common peroneal nerve. After 0, 8, 12, or 22 weeks of denervation, animals were assigned to either a direct repair or a neurotization cohort. An additional 7 animals were used for a sham cohort, and 7 of the 58 were used as controls. After a 12-week recovery period, animals had contractile strength and EMG testing of the tibialis anterior muscle. Peak force and characteristics were compared to the unoperated, contralateral limb. Tibialis anterior muscles were then harvested for mass and histologic evaluation. Results Sixty-two animals completed testing. Denervated controls demonstrated a significant decrease in muscle mass, contractile strength, and peak motor nerve conduction amplitude compared to sham animals. In all groups, chronicity of denervation adversely affected functional recovery. On average, repair animals performed better than neurotization animals with respect to muscle mass, contractile strength, and peak motor amplitude. Differences in contractile force, however, were significant only at the 0 week denervation group (94% ± 30 vs 50% ± 20, repair vs neurotization). Neurotized muscles processed for histologic analysis demonstrated acetylcholinesterase activity at the nerve-muscle interface, confirming the formation of motor end plates de novo. Conclusions We demonstrated that neurotization is capable of reinnervating de novo end plates in chronically denervated muscle. Our data do not support the hypothesis that direct muscle neurotization is superior to nerve repair for functional restoration of chronically denervated muscle. However, as the duration of denervation increases, the difference between outcomes of the neurotization and repair group narrows, suggesting that neurotization may offer a viable surgical alternative in the setting of prolonged denervation.
has issue date	2008-09-30(xsd:dateTime)
bibo:doi	10.1016/j.jhsa.2008.02.025
bibo:pmid	18762103
has license	els-covid
sha1sum (hex)	992395a1a5a3e251c52be71ff12a1c1f768d23f9
schema:url	https://doi.org/10.1016/j.jhsa.2008.02.025
resource representing a document's title	Comparison of Neurotization Versus Nerve Repair in an Animal Model of Chronically Denervated Muscle
has PubMed Central identifier	PMC7126155
has PubMed identifier	18762103
schema:publication	The Journal of Hand Surgery
resource representing a document's body	covid:992395a1a5a3e251c52be71ff12a1c1f768d23f9#body_text
is schema:about of	named entity 'COMPARISON' named entity 'muscle' named entity 'compare' named entity 'strategies' named entity 'Animal' named entity 'DIRECT' named entity 'DENERVATED' named entity 'NERVE REPAIR' named entity 'RECOVERY' named entity 'INCLUDE' named entity 'REINNERVATION' named entity 'CHRONIC DENERVATION' named entity 'NERVE TRANSFER' named entity 'STRATEGIES' named entity 'EITHER' named entity 'CHRONICALLY' named entity 'MODEL OF' named entity 'NERVE GRAFTING' named entity 'CURRENT' named entity 'STUDY' named entity 'RAT MODEL' named entity 'MUSCLE' named entity 'CHRONICALLY' named entity 'ANIMAL MODEL' named entity 'NEUROTIZATION' named entity 'NERVE REPAIR' named entity 'MUSCLE' named entity 'REPAIR' named entity 'GOAL' named entity 'UNDERSTOOD' named entity 'NEUROTIZATION' named entity 'TO COMPARE' named entity 'USING' named entity 'PURPOSE' named entity 'POORLY' named entity 'DENERVATED' named entity 'MODEL OF' named entity 'OPERATIVE' covid:arg/992395a1a5a3e251c52be71ff12a1c1f768d23f9 named entity 'denervated' named entity 'rat' named entity 'denervation' named entity 'denervation' named entity 'nerve conduction studies' named entity 'distal' named entity 'tetanic contraction' named entity 'significant effect' named entity 'motor neurons' named entity '2.2' named entity 'denervation' named entity 'denervated' named entity 'suture' named entity 'tibialis anterior' named entity 'epimysium' named entity 'nerve terminals' named entity 'tetanic contraction' named entity 'denervated' named entity 'tibial nerve' named entity 'denervated' named entity 'Reckitt Benckiser' named entity 'Institutional Animal Care and Use Committee' named entity 'reinnervation' named entity 'Transducer' named entity 'axons' named entity 'denervated' named entity 'foam board' named entity 'tetanic' named entity 'reinnervate' named entity 'Muscle mass' named entity 'load cell' named entity 'animal model' named entity 'sensory nerve' named entity 'primate' named entity 'Ethicon, Inc.' named entity 'denervated' named entity 'Temecula'

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