About: Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics

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About: Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics
Creator	Tse, Herman Yuen, Kwok-Yung Chen, Zhiwei Zhang, Linqi Huang, Jian-Dong Yang, Dan Chan, Kwok-Hung Chen, Guanhua He, Tian Hu, Lihong Tsoi, Hoi-Wah Wong, Bonnie Kao, Richard Lee, Terri Ng, Louisa Tanner, Julian To, Amanda Tsui, Wayne Ho, David Watt, Rory
topic	covid:993a4ec640e7411cea67abb9b520ceab732fb883#this
Source	Elsevier; Medline; PMC
abstract	Abstract The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infected more than 8,000 people across 29 countries and caused more than 900 fatalities. Based on the concept of chemical genetics, we screened 50,240 structurally diverse small molecules from which we identified 104 compounds with anti-SARS-CoV activity. Of these 104 compounds, 2 target the SARS-CoV main protease (Mpro), 7 target helicase (Hel), and 18 target spike (S) protein-angiotensin-converting enzyme 2 (ACE2)-mediated viral entry. The EC50 of the majority of the 104 compounds determined by SARS-CoV plaque reduction assay were found to be at low micromolar range. Three selected compounds, MP576, HE602, and VE607, validated to be inhibitors of SARS-CoV Mpro, Hel, and viral entry, respectively, exhibited potent antiviral activity (EC50 < 10 μM) and comparable inhibitory activities in target-specific in vitro assays.
has issue date	2004-09-30(xsd:dateTime)
bibo:doi	10.1016/j.chembiol.2004.07.013
bibo:pmid	15380189
has license	els-covid
sha1sum (hex)	993a4ec640e7411cea67abb9b520ceab732fb883
schema:url	https://doi.org/10.1016/j.chembiol.2004.07.013
resource representing a document's title	Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics
has PubMed Central identifier	PMC7128553
has PubMed identifier	15380189
schema:publication	Chemistry & Biology
resource representing a document's body	covid:993a4ec640e7411cea67abb9b520ceab732fb883#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/993a4ec640e7411cea67abb9b520ceab732fb883
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