About: Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different species

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About: Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different species
Creator	Zhao, Jincun Tang, Yan-Dong Wang, Tong-Yun Zhang, Hong-Liang Yang, Yue-Lin Sun, Ming-Xia Cai, Xui-Hui Hu, Xiao-Liang Li, Yu -Ming
source	BioRxiv
abstract	The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a huge threat to many countries around the world. However, where is it origin and which animals are sensitive to cross-species transmission is unclear. The interaction of virus and cell receptor is a key determinant of host range for the novel coronavirus. Angiotensin-converting enzyme 2 (ACE2) is demonstrated as the primary entry receptor for SARS-CoV-2. In this study, we evaluated the SARS-CoV-2 entry mediated by ACE2 of 11 different species of animals, and discovered that ACE2 of Rhinolophus sinicus (Chinese horseshoe bat), Felis catus (domestic cat), Canis lupus familiaris (dog), Sus scrofa (pig), Capra hircus (goat) and especially Manis javanica (Malayan pangolin) were able to render SARS-CoV-2 entry in non-susceptible cells. This is the first report that ACE2 of Pangolin could mediate SARS-CoV-2 entry which increases the presume that SARS-CoV-2 may have a pangolin origin. However, none of the ACE2 proteins from Rhinolophus ferrumequinum (greater horseshoe bat), Gallus gallus (chicken), Notechis scutatus (mainland tiger snake), Mus musculus (house mouse) rendered SARS-CoV-2 entry. Specifically, a natural isoform of Macaca mulatta (Rhesus monkey) ACE2 with a mutation of Y217N was resistance to infection, which rises the possible impact of this type of ACE2 during monkey studies of SARS-CoV-2. Overall, these results clarify that SARS-CoV-2 could engage receptors of multiple species of animals and it is a perplexed work to track SARS-CoV-2 origin and its intermediate hosts. IMPORTANCE In this study, we illustrated that SARS-CoV-2 is able to engage receptors of multiple species of animals. This indicated that it may be a perplexed work to track SARS-CoV-2 origin and discover its intermediate hosts. This feature of virus is considered to potentiate its diverse cross-species transmissibility. Of note, here is the first report that ACE2 of Pangolin could mediate SARS-CoV-2 entry which increases the possibility that SARS-CoV-2 may have a pangolin origin. And we also demonstrated that not all species of bat were sensitive to SARS-CoV-2 infection. At last, it is also important to detect the expression ratio of the Y217N ACE2 to the prototype in Rhesus monkeys to be recruited for studies on SARS-CoV-2 infection.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1101/2020.06.15.153916
has license	biorxiv
sha1sum (hex)	994d6fe26ffd4139910967a6895cb02e7ad8f32c
schema:url	https://doi.org/10.1101/2020.06.15.153916
resource representing a document's title	Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different species
schema:publication	bioRxiv
resource representing a document's body	covid:994d6fe26ffd4139910967a6895cb02e7ad8f32c#body_text
is schema:about of	named entity 'impact' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'Rhinolophus' named entity 'ACE2' named entity 'mediated' named entity 'TIGER SNAKE' named entity 'HUGE' named entity 'discovered' named entity 'sensitive' named entity 'Capra' named entity 'origin' named entity 'SARS-CoV-2' named entity 'mutation' named entity 'mediate' named entity 'pangolin' named entity 'infection' named entity 'proteins' named entity 'SARS-CoV-2' named entity 'Felis catus' named entity 'Sus scrofa' named entity 'origin' named entity 'horseshoe bat' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Capra hircus' named entity 'Mus musculus' named entity 'Rhinolophus' named entity 'greater horseshoe bat' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'house mouse' named entity 'tiger snake' named entity 'ACE2' named entity 'Sus scrofa' named entity 'ACE2' named entity 'host tropism' named entity 'China' named entity '1, 2' named entity 'Rhinolophus' named entity 'clinical symptoms' named entity 'ACE2' named entity 'causative agent' named entity 'GenBank' named entity 'Greater horseshoe bat' named entity 'transmissibility' named entity 'ACE2' named entity 'Rhesus monkey' named entity 'natural reservoir' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'cross-species' named entity 'MERS-CoV' named entity 'primary cell' named entity 'infection' named entity 'DPP4' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'house mouse' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Macaca mulatta' named entity 'SARS-CoV-2 outbreak' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'cell entry' named entity 'bat species' named entity 'infection' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'cross-species transmission' named entity 'SARS-CoV-2' named entity 'pig' named entity 'Macaca mulatta' named entity 'angiotensin-converting enzyme 2' named entity 'SARS-CoV-2'

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