About: A G1-lineage H9N2 virus with oviduct tropism causes chronic pathological changes in the infundibulum and a long-lasting drop in egg production

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About: A G1-lineage H9N2 virus with oviduct tropism causes chronic pathological changes in the infundibulum and a long-lasting drop in egg production Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A G1-lineage H9N2 virus with oviduct tropism causes chronic pathological changes in the infundibulum and a long-lasting drop in egg production
Creator	Cattoli, Giovanni Terregino, Calogero Bigolaro, Michela Bonfante, Francesco Davidson, Irit Fortin, Andrea Gobbo, Federica Haddas, Ruth Maniero, Silvia Mazzetto, Eva Zanardello, Claudia
topic	covid:9984d00caafab39f1c5673c4f7cc53fbddf0b8e9#this
Source	Medline; PMC
abstract	Since 1997, G1-lineage H9N2 avian influenza viruses have been circulating in Asia and later on in the Middle East, and they have been associated to mild respiratory disease, drops in egg production and moderate mortality in chickens, in particular in the presence of concurrent infections. In this study, we investigated the importance of the G1-lineage H9N2 A/chicken/Israel/1163/2011 virus as a primary pathogen in layers, analyzing its tropism and binding affinity for the oviduct tissues, and investigating the long-term impact on egg production. Besides causing a mild respiratory infection, the virus replicated in the oviduct of 60% of the hens causing different degrees of salpingitis throughout the organ, in particular at the level of the infundibulum, where the detection of the virus was associated with severe heterophilic infiltrate, and necrosis of the epithelium. Binding affinity assays confirmed that the infundibulum was the most receptive region of the oviduct. The drop in egg production was at its peek at 2 weeks post-infection (pi) (60% decrease) and continued up to 80 days pi (35% decrease). On day 80 pi, non-laying birds showed egg yolk peritonitis, and histopathological analyses described profound alteration of the infundibulum architecture, duct ectasia and thinning of the epithelium, while the rest of the oviduct and ovary appeared normal. Our results show that this H9N2 virus is a primary pathogen in layer hens, and that its replication in the infundibulum is responsible for acute and chronic lesions that limits the effective functionality of the oviduct, compromising the commercial life of birds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-018-0575-1) contains supplementary material, which is available to authorized users.
has issue date	2018-08-29(xsd:dateTime)
bibo:doi	10.1186/s13567-018-0575-1
bibo:pmid	30157967
has license	cc-by
sha1sum (hex)	9984d00caafab39f1c5673c4f7cc53fbddf0b8e9
schema:url	https://doi.org/10.1186/s13567-018-0575-1
resource representing a document's title	A G1-lineage H9N2 virus with oviduct tropism causes chronic pathological changes in the infundibulum and a long-lasting drop in egg production
has PubMed Central identifier	PMC6116506
has PubMed identifier	30157967
schema:publication	Vet Res
resource representing a document's body	covid:9984d00caafab39f1c5673c4f7cc53fbddf0b8e9#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9984d00caafab39f1c5673c4f7cc53fbddf0b8e9
is schema:about of	named entity 'ANALYZING' named entity 'ALTERATION' named entity 'PATHOLOGICAL' named entity 'UP TO' named entity 'MODERATE' named entity '1997' named entity 'CONTINUED' named entity 'RESPONSIBLE' named entity 'PRESENCE OF' named entity 'STUDY' named entity 'CAUSES' named entity 'EGG PRODUCTION' named entity 'CHRONIC' named entity 'DROP' named entity 'RESULTS' named entity 'HETEROPHILIC' named entity 'DEGREES' named entity 'PEEK' named entity 'AVIAN INFLUENZA' covid:arg/9984d00caafab39f1c5673c4f7cc53fbddf0b8e9 named entity 'CHICKENS' named entity 'REST OF' named entity 'LIFE' named entity 'ORGAN' named entity 'CHRONIC' named entity 'NON-' named entity 'REPLICATION' named entity 'TROPISM' named entity 'INFUNDIBULUM' named entity 'DROPS' named entity 'INFILTRATE' named entity 'ASSOCIATED' named entity 'SALPINGITIS' named entity 'OVIDUCT' named entity 'EGG YOLK' named entity 'ITS' named entity 'CONFIRMED' named entity 'INFECTIONS' named entity 'LINEAGE' named entity 'LONG' named entity 'CHANGES' named entity 'H9N2 VIRUS' named entity 'HISTOPATHOLOGICAL' named entity 'CONCURRENT' named entity 'VIRUS' named entity 'PARTICULAR' named entity 'LIMITS' named entity 'INFUNDIBULUM' named entity 'DETECTION' named entity 'CAUSING' named entity 'RESPIRATORY INFECTION' named entity 'POST' named entity 'INFLUENZA VIRUSES' named entity 'REPLICATED' named entity 'IS A' named entity '2860' named entity 'BIRDS' named entity 'OUR' named entity 'MIDDLE EAST' named entity 'SEVERE' named entity 'EFFECTIVE' named entity 'DIFFERENT' named entity 'DAYS' named entity 'DECREASE' named entity 'THINNING' named entity 'LATER' named entity 'MORTALITY' named entity 'MILD' named entity 'WHERE'

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