About: Human Bocavirus and Acute Wheezing in Children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Bocavirus and Acute Wheezing in Children
Creator	Vuorinen, Tytti Jartti, Tuomas Ruuskanen, Olli Waris, Matti Allander, Tobias Lehtinen, Pasi Bjerkner, Annelie Niesters, Hubert Van Den Hoogen, Bernadette Hyypiä, Timo Sterback, Riikka Gupta, Shawon Tiveljung-Lindell, Annika
Source	Medline; PMC
abstract	Background. Human bocavirus is a newly discovered parvovirus. It has been detected primarily in children with acute lower respiratory tract infection, but its occurrence, clinical profile, and role as a causative agent of respiratory tract disease are not clear. Methods. We investigated the presence of human bocavirus by quantitative polymerase chain reaction of nasopharyngeal aspirate specimens and selected serum samples obtained from 259 children (median age, 1.6 years) who had been hospitalized for acute expiratory wheezing. The samples were analyzed for 16 respiratory viruses by polymerase chain reaction, virus culture, antigen detection, and serological assays. Results. At least 1 potential etiologic agent was detected in 95% of children, and >1 agent was detected in 34% of children. Human bocavirus was detected in 49 children (19%). A large proportion of the cases were mixed infections with other viruses, but human bocavirus was the only virus detected in 12 children (5%). High viral loads of human bocavirus were noted mainly in the absence of other viral agents, suggesting a causative role for acute wheezing. In addition, infections that had uncertain clinical relevance and low viral loads were prevalent. Human bocavirus DNA was frequently detected in serum specimens obtained from patients with acute wheezing, suggesting systemic infection. Conclusions. Human bocavirus is prevalent among children with acute wheezing and can cause systemic infection. Results suggest a model for bocavirus infection in which high viral loads are potentially associated with respiratory symptoms and low viral loads indicate asymptomatic shedding. Therefore, quantitative polymerase chain reaction analysis may be important for additional studies of human bocavirus.
has issue date	2007-04-01(xsd:dateTime)
bibo:doi	10.1086/512196
bibo:pmid	17342639
has license	no-cc
sha1sum (hex)	99a160a97cb528fadfc752b87b9c1f24afa55b4c
schema:url	https://doi.org/10.1086/512196
resource representing a document's title	Human Bocavirus and Acute Wheezing in Children
has PubMed Central identifier	PMC7107819
has PubMed identifier	17342639
schema:publication	Clin Infect Dis
resource representing a document's body	covid:99a160a97cb528fadfc752b87b9c1f24afa55b4c#body_text
is schema:about of	named entity 'Background' named entity 'Human bocavirus' covid:arg/99a160a97cb528fadfc752b87b9c1f24afa55b4c named entity 'discovered' named entity 'respiratory tract disease' named entity 'parvovirus' named entity 'lower respiratory tract infection' named entity 'respiratory tract infection' named entity 'Viral antigens' named entity 'nasopharynx' named entity 'serum' named entity 'virus' named entity 'serum samples' named entity 'respiratory symptoms' named entity 'respiratory tract' named entity 'asymptomatic' named entity 'gene' named entity 'C-reactive protein' named entity 'A549' named entity 'Real-time PCR' named entity 'enteroviruses' named entity 'placebo-controlled clinical trial' named entity 'Fisher's exact test' named entity 'Roche' named entity 'enteroviruses' named entity 'Applied Biosystems' named entity 'serum samples' named entity 'infection' named entity 'viral load' named entity 'young children' named entity 'adenovirus' named entity 'PCR' named entity 'causality' named entity 'asymptomatic' named entity 'nasopharyngeal aspirate' named entity 'wheezing' named entity 'clinically significant' named entity 'randomly selected' named entity 'Europe' named entity 'control subjects' named entity 'viruses' named entity 'infection' named entity 'parainfluenza virus' named entity 'serum samples' named entity 'wheezing' named entity 'Qiagen' named entity 'virus' named entity 'Signs and symptoms' named entity 'coronavirus' named entity 'gene' named entity 'viral pathogen' named entity 'wheezing' named entity 'virus' named entity 'mixed infections' named entity 'bovine serum albumin' named entity 'fibroblast cells' named entity 'C-reactive protein' named entity 'virus' named entity 'acute otitis media' named entity 'RSV' named entity 'viruses' named entity 'wheezing' named entity 'viral load' named entity 'viruses' named entity 'human foreskin' named entity 'respiratory tract' named entity 'diagnostic criteria' named entity 'virus' named entity 'nasopharynx'

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