About: Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase

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About: Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase
Creator	Oh, Jong-Won Kim, Seong-Jun Ahn, Dae-Gyun Choi, Jin-Kyu Kang, Su-Min Kim, Jung-Hee
Source	Elsevier; Medline; PMC
abstract	Abstract The hepatitis C virus (HCV) core protein is a structural component of the nucleocapsid and has been shown to modulate cellular signaling pathways by interaction with various cellular proteins. In the present study, we investigated the role of HCV core protein in viral RNA replication. Immunoprecipitation experiments demonstrated that the core protein binds to the amino-terminal region of RNA-dependent RNA polymerase (RdRp), which encompasses the finger and palm domains. Direct interaction between HCV RdRp and core protein led to inhibition of RdRp RNA synthesis activity of in vitro. Furthermore, over-expression of core protein, but not its derivatives lacking the RdRp-interacting domain, suppressed HCV replication in a hepatoma cell line harboring an HCV subgenomic replicon RNA. Collectively, our results suggest that the core protein, through binding to RdRp and inhibiting its RNA synthesis activity, is a viral regulator of HCV RNA replication.
has issue date	2009-08-14(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2009.05.129
bibo:pmid	19501052
has license	els-covid
sha1sum (hex)	99a5195bd450069da02d3496508c735403b3958c
schema:url	https://doi.org/10.1016/j.bbrc.2009.05.129
resource representing a document's title	Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase
has PubMed Central identifier	PMC7092928
has PubMed identifier	19501052
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:99a5195bd450069da02d3496508c735403b3958c#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'BUT' named entity 'STUDY' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'EXPERIMENTS' named entity 'HARBORING' named entity 'OUR' named entity 'VIRAL' named entity 'REPLICATION' named entity 'AMINO' named entity 'PALM' named entity 'IMMUNOPRECIPITATION' named entity 'DOMAIN' named entity 'HEPATITIS C VIRUS' named entity 'ITS' named entity 'PROTEIN ' named entity 'MODULATE' named entity 'RDRP' named entity 'RNA' named entity 'hepatitis C virus' named entity 'RdRp' named entity 'RNA' named entity 'modulate' named entity 'interaction' named entity 'ITS' named entity 'IN VITRO' named entity 'ACTIVITY' named entity 'HEPATITIS C VIRUS' named entity 'VIRUS REPLICATION' named entity 'VIRAL RNA' named entity 'RNA POLYMERASE' named entity 'PRESENT' named entity 'TERMINAL' named entity 'CELLULAR' named entity 'VARIOUS' named entity 'EXPRESSION' named entity 'NUCLEOCAPSID' named entity 'REPLICON' named entity 'INHIBITION OF RDRP' named entity 'SUPPRESSED' named entity 'STRUCTURAL COMPONENT' named entity 'RNA SYNTHESIS' named entity 'CORE PROTEIN' named entity 'INTERACTION' named entity 'REGION' named entity 'INTERACTING' named entity 'INVESTIGATED' named entity 'PROTEINS' named entity 'RNA REPLICATION' named entity 'INHIBITING' named entity 'LACKING' named entity 'VIRAL RNA' named entity 'CORE PROTEIN' named entity 'BINDING' named entity 'DEMONSTRATED' named entity 'REGULATOR' named entity 'REGULATION' named entity 'SUGGEST' named entity 'DIRECT INTERACTION' named entity 'BINDS' named entity 'ROLE' named entity 'LED' named entity 'FINGER' named entity 'RNA' named entity 'RESULTS' named entity 'SIGNALING PATHWAYS' named entity 'HCV' named entity 'IS A' named entity 'HEPATOMA CELL LINE' named entity 'INTERACTION' covid:arg/99a5195bd450069da02d3496508c735403b3958c named entity 'HCV' named entity 'HCV' named entity 'finger' named entity 'HCV' named entity 'RNA'

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