About: IFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections

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About: IFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections
Creator	Tang, Wei Ambs, Stefan Obajemu, Adeola Prokunina-Olsson, Ludmila Dorsey, Tiffany Jordan, Symone Loffredo, Christopher Minas, Tsion Obadi, Obadi Onabajo, Olusegun Ryan, Bríd Smith, Cheryl
source	Medline; PMC
abstract	Sexually transmitted infections can reach the prostate gland where their harmful effects are mediated by innate immunity, including interferons. Humans are polymorphic for the germline dinucleotide variant, rs368234815-TT/ΔG, in the IFNL4 gene encoding interferon λ4. Since the IFNL4-ΔG allele has been linked to impaired viral clearance, we hypothesized that potential exposure to sexually transmitted pathogens, as assessed by the number of lifetime sexual partners, may increase prostate cancer risk in an IFNL4-ΔG-dependent manner. Accordingly, we find that men with 10 or more sexual partners and at least one copy of IFNL4-ΔG have a significantly increased risk of prostate cancer while those with the same number of partners but lacking IFNL4-ΔG do not. Moreover, a test for effect modification shows a positive interaction between the number of lifetime partners and IFNL4-ΔG in the development of aggressive prostate cancer. Based on these findings, we conclude that a gene–environment interaction between IFNL4-ΔG and sexual activity may increase the risk of prostate cancer.
has issue date	2018-11-14(xsd:dateTime)
bibo:doi	10.1038/s42003-018-0193-5
bibo:pmid	30456312
has license	cc-by
sha1sum (hex)	99acb5c35e12a8faa8d0f4bc507642a63713414f
schema:url	https://doi.org/10.1038/s42003-018-0193-5
resource representing a document's title	IFNL4-ΔG is associated with prostate cancer among men at increased risk of sexually transmitted infections
has PubMed Central identifier	PMC6235841
has PubMed identifier	30456312
schema:publication	Commun Biol
resource representing a document's body	covid:99acb5c35e12a8faa8d0f4bc507642a63713414f#body_text
is schema:about of	named entity 'copy' named entity 'sexual partners' named entity 'pathogens' named entity 'polymorphic' named entity 'prostate cancer' named entity 'SEXUALLY TRANSMITTED' named entity 'PROSTATE CANCER' named entity 'BUT' named entity 'REACH' named entity 'SEXUAL PARTNERS' named entity 'HAVE' named entity 'INCREASED RISK' named entity 'HARMFUL' named entity 'THESE' named entity 'IFNL4 GENE' named entity 'LIFETIME' named entity 'BASED' named entity 'POLYMORPHIC' named entity 'PARTNERS' named entity 'EFFECT' named entity 'NUMBER OF' named entity 'DEPENDENT' named entity 'THEIR' named entity 'RISK OF' named entity 'IFNL4' named entity 'BB4' named entity 'ALLELE' named entity 'POTENTIAL' named entity 'SEXUALLY TRANSMITTED INFECTIONS' named entity 'MEDIATED' named entity 'HUMANS' named entity 'DINUCLEOTIDE' named entity 'LACKING' named entity 'VIRAL CLEARANCE' named entity 'DO NOT' named entity 'EXPOSURE TO' named entity 'POSITIVE' named entity 'WHERE' named entity 'GERMLINE' named entity 'ASSESSED' named entity 'IFNL4' named entity 'PROSTATE CANCER RISK' named entity 'CONCLUDE' named entity 'INCREASED RISK' named entity 'INTERACTION' named entity 'ENCODING' named entity 'VARIANT' named entity 'A GENE' named entity 'PROSTATE GLAND' named entity 'DEVELOPMENT' named entity 'OF PROSTATE CANCER' named entity 'AGGRESSIVE' named entity 'TEST' named entity '10 OR MORE' named entity 'INCLUDING' named entity 'EFFECTS' named entity 'INNATE IMMUNITY' named entity 'RISK OF' named entity 'SEXUALLY TRANSMITTED INFECTIONS' named entity 'MEN' named entity 'INTERFERONS' named entity 'SEXUAL ACTIVITY' named entity 'PATHOGENS' named entity 'GENE-ENVIRONMENT INTERACTION' named entity 'COPY' named entity 'MEN' named entity 'FINDINGS' named entity 'PROSTATE CANCER' named entity 'ASSOCIATED WITH' named entity 'MODIFICATION'

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