About: Clinical Characteristics and Prognosis of 218 Patients With COVID-19: A Retrospective Study Based on Clinical Classification

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About: Clinical Characteristics and Prognosis of 218 Patients With COVID-19: A Retrospective Study Based on Clinical Classification Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Characteristics and Prognosis of 218 Patients With COVID-19: A Retrospective Study Based on Clinical Classification
Creator	Fan, Yong Chen, Fang Li, Yimin Lin, Wei Kozlakidis, Zisis Long, Da Fang, Zhixiong Han, Xiaotong Peng, Danhong Xie, Yu Yan, Xiquan Zhu, Shuibo Zhu, Yimin Takir, Huriye Xie, Long
source	Medline; PMC
abstract	Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has spread worldwide. Methods: This was a retrospective case series involving 218 patients admitted to three tertiary hospitals in the Loudi, Shaoyang, and Xiangtan areas of China from January 21 to June 27, 2020, who were confirmed by RT-PCR to have SARS-CoV-2. The patients' clinical characteristics, laboratory results, treatments, and prognoses based on clinical classification were recorded. Poor outcome was defined as admission to an ICU, the use of mechanical ventilation, or death. Results: The patients were classified into four clinical groups based on disease severity, namely mild (10/218, 5%), moderate (146/218, 67%), severe (24/218, 11%), or critical (14/218, 6%); 24 (11%) asymptomatic cases were also included in the study. The most common symptoms were self-reported cough (162/218, 74%), fever (145/218, 67%), sputum production (99/218, 45%), and fatigue (77/218, 35%). Among the 218 patients, 192 (88%) received lopinavir/ritonavir and interferon-alpha inhalation, and 196 (90%) patients received traditional Chinese medicine. Among the severe and critical patients, 25 (11%) were admitted to an ICU with or without mechanical ventilation, and one patient died. The presence of diabetes [relative risk (RR), 3.0; 95% CI, 1.3–6.8; p = 0.007) or other comorbidities (RR, 5.9; 95% CI, 1.9–17.8; p = 0.002) was independently associated with poor outcome. To date, 20 (9%) patients have retested positive for SARS-CoV-2 RNA after recovering and being discharged. Conclusion: The majority of patients in this case series were clinically classified as having moderate COVID-19. Older patients tended to present with greater levels of clinical severity. The prognosis for patients who were elderly or had diabetes or other chronic comorbidities was relatively poor.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.3389/fmed.2020.00485
bibo:pmid	32850925
has license	cc-by
sha1sum (hex)	99ae775aa5c46730a9d4b4747c4b8aa7b34f622f
schema:url	https://doi.org/10.3389/fmed.2020.00485
resource representing a document's title	Clinical Characteristics and Prognosis of 218 Patients With COVID-19: A Retrospective Study Based on Clinical Classification
has PubMed Central identifier	PMC7431472
has PubMed identifier	32850925
schema:publication	Front Med (Lausanne)
resource representing a document's body	covid:99ae775aa5c46730a9d4b4747c4b8aa7b34f622f#body_text
is schema:about of	named entity 'Clinical Characteristics' named entity 'COVID-19' named entity 'post-hoc test' named entity 'standard error' named entity 'comorbid conditions' named entity 'clinical features' named entity 'viral pneumonia' named entity 'Loudi' named entity 'Asymptomatic' named entity 'ground-glass opacities' named entity 'quarantine' named entity 'antiviral therapies' named entity 'Asymptomatic patients' named entity 'Coronavirus disease 2019' named entity 'COVID' named entity 'cough' named entity 'clinical practice guidelines' named entity 'Hunan' named entity 'chronic diseases' named entity 'APTT' named entity 'prognosis' named entity 'medical conditions' named entity 'demographic' named entity 'RT-PCR' named entity 'SPSS' named entity 'Xiangtan' named entity 'treatment protocol' named entity 'decoction' named entity 'COVID-19' named entity 'ICU' named entity 'catheter' named entity 'antibiotics' named entity 'retrospective studies' named entity 'CT scans' named entity 'route of transmission' named entity '95% CI' named entity 'COVID' named entity 'hypertension' named entity 'Kaplan-Meier' named entity 'survival analysis' named entity 'comorbid' named entity 'mechanical ventilation' named entity 'reduce the spread' named entity 'diabetes' named entity 'mechanical ventilation' named entity 'Fisher's exact test' named entity 'prognosis' named entity 'severe pneumonia' named entity 'Lactate dehydrogenase' named entity 'pulmonary consolidation' named entity 'crude mortality rate' named entity 'mechanical ventilation' named entity 'chronic diseases' named entity 'fatigue' named entity 'SARS-CoV-2' named entity 'oxygen therapy' named entity 'diabetes' named entity 'comorbid' named entity 'Berlin' named entity 'CT imaging' named entity 'sputum production' named entity 'province of China' named entity 'patient care' named entity 'antibacterial agents' named entity 'cough' named entity 'univariate analysis' named entity 'China'

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