About: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

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About: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
Creator	Zhao, Yan Kellam, Paul Dong, Tao Li, Ning Wu, Hao Jin, Rong-Hua Ho, Ling-Pei Liu, Ning Giannoulatou, Eleni Liu, Jin-Hua Peng, Yan-Chun Shu, Yue-Long Wang, Da-Yan Yan, Hui-Ping Zhang, Yong-Hong Mcmichael, Andrew
Source	Medline; PMC
abstract	The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
has issue date	2013-01-29(xsd:dateTime)
bibo:doi	10.1038/ncomms2433
bibo:pmid	23361009
has license	cc-by-nc-sa
sha1sum (hex)	99c9c1e5588a8e109e0e82cc66acea4dc5808a02
schema:url	https://doi.org/10.1038/ncomms2433
resource representing a document's title	Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
has PubMed Central identifier	PMC3562464
has PubMed identifier	23361009
schema:publication	Nat Commun
resource representing a document's body	covid:99c9c1e5588a8e109e0e82cc66acea4dc5808a02#body_text
is schema:about of	named entity 'INFLUENZA' named entity 'SEVERE' named entity 'MUCH' named entity 'ITS' named entity 'POPULATION' named entity 'VIRUS INFECTION' named entity 'NORTHERN' named entity 'GREATER' named entity 'DESCENT' named entity 'CHINESE' named entity 'PATIENTS' named entity 'CC GENOTYPE' named entity 'HIGH FREQUENCY' named entity 'BUT' named entity 'CAUCASIANS' named entity 'STRONG' named entity 'EFFECT' named entity 'VARIANTS' named entity 'FUNCTION' named entity 'SNP' named entity 'CHINA' named entity 'strong' named entity 'epidemiology' named entity 'Europeans' named entity 'influenza' named entity 'patients' named entity 'INDIVIDUALS' covid:arg/99c9c1e5588a8e109e0e82cc66acea4dc5808a02 named entity 'DISEASE SEVERITY' named entity 'COMPARED' named entity 'HAVE' named entity 'INCREASING' named entity 'INTERFERON-INDUCED TRANSMEMBRANE PROTEIN' named entity 'SEVERE INFECTION' named entity 'GENOTYPE' named entity 'CHINESE' named entity 'ARTICLE' named entity 'INFECTION' named entity 'ESTIMATED' named entity 'HAN CHINESE' named entity 'INFLUENZA' named entity 'EPIDEMIOLOGY' named entity 'RISK' named entity 'POPULATION-ATTRIBUTABLE RISK' named entity 'GENOTYPES' named entity 'INTERFERON-INDUCED TRANSMEMBRANE PROTEIN' named entity 'MILD' named entity 'HERE' named entity '5.4' named entity 'LARGE' named entity 'PEOPLE' named entity 'INFLUENZA A' named entity 'SEVERE' named entity 'H1N1' named entity 'ASSOCIATED WITH' named entity 'FOUND' named entity 'INFLUENZA VIRUS' named entity 'GENETIC' named entity 'RARE' named entity 'ALLELE' named entity 'COMMON' named entity 'EUROPEANS' named entity 'REPORT' named entity 'PANDEMIC' named entity 'RISK OF' named entity 'disease'

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