About: The cytokine storm of severe influenza and development of immunomodulatory therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The cytokine storm of severe influenza and development of immunomodulatory therapy
Creator	Liu, Qiang Yang, Zhan-Qiu Zhou, Yuan-Hong
Source	Medline; PMC
abstract	Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are often associated with hyperinduction of proinflammatory cytokine production, which is also known as ‘cytokine storm'. For this disease, it has been proposed that immunomodulatory therapy may improve the outcome, with or without the combination of antiviral agents. Here, we review the current literature on how various effectors of the immune system initiate the cytokine storm and exacerbate pathological damage in hosts. We also review some of the current immunomodulatory strategies for the treatment of cytokine storms in severe influenza, including corticosteroids, peroxisome proliferator-activated receptor agonists, sphingosine-1-phosphate receptor 1 agonists, cyclooxygenase-2 inhibitors, antioxidants, anti-tumour-necrosis factor therapy, intravenous immunoglobulin therapy, statins, arbidol, herbs, and other potential therapeutic strategies.
has issue date	2015-07-20(xsd:dateTime)
bibo:doi	10.1038/cmi.2015.74
bibo:pmid	26189369
has license	bronze-oa
sha1sum (hex)	9a2861a88c29eff57124d757c0a24dd6bee7b462
schema:url	https://doi.org/10.1038/cmi.2015.74
resource representing a document's title	The cytokine storm of severe influenza and development of immunomodulatory therapy
has PubMed Central identifier	PMC4711683
has PubMed identifier	26189369
schema:publication	Cellular & Molecular Immunology
resource representing a document's body	covid:9a2861a88c29eff57124d757c0a24dd6bee7b462#body_text
is schema:about of	named entity 'INFLUENZA' named entity 'DEVELOPMENT' named entity 'SEVERE' named entity 'IMMUNOMODULATORY THERAPY' named entity 'CYTOKINE STORM' named entity 'cytokine storm' named entity 'immunomodulatory' named entity 'pathogen-associated molecular pattern' named entity 'neuraminidase inhibitor' named entity 'blood flow' named entity 'reduce inflammation' named entity 'epithelial' named entity 'cytokines' named entity 'anti-inflammatory' named entity 'immunomodulatory' named entity 'randomized clinical trials' named entity 'corticosteroids' named entity 'Th2' named entity 'meta-analysis' named entity 'immune cells' named entity 'CD134' named entity 'immunomodulatory' named entity 'caffeine' named entity 'azithromycin' named entity 'H5N1' named entity 'immune response' named entity 'monotherapy' named entity 'receptor agonists' named entity 'chemokine receptors' named entity 'signaling pathways' named entity 'cytokine' named entity 'ARBs' named entity 'antioxidants' named entity 'erythromycin' named entity 'clinical trials' named entity 'murine models' named entity 'virus' named entity 'blood vessels' named entity 'H5N1' named entity 'cytokine storm' named entity 'influenza virus' named entity 'IL-1b' named entity 'viral pneumonia' named entity 'cells to migrate' named entity 'ARBs' named entity 'Adenosine' named entity 'oseltamivir' named entity 'IL-1 receptor' named entity 'inflammatory response' named entity 'influenza' named entity 'cytokines' named entity 'H5N1' named entity 'N-acetylcysteine' named entity 'influenza' named entity 'MCP-1' named entity 'necrosis' named entity 'cellular immune responses' named entity 'inflammatory state' named entity 'clinical trial' named entity 'influenza' named entity 'immunopathology' named entity 'plasma' named entity 'cytokine' named entity 'immune response' named entity 'signaling cascades' named entity 'gene expression' named entity 'fusion protein' named entity 'chemokines' named entity 'cytokine-storm' named entity 'pro-inflammatory cytokine' named entity 'pneumonia' named entity 'influenza' named entity 'clinical trials' named entity 'cytokine storm' named entity 'COX-2 inhibitors' named entity 'agonists' named entity 'tissue damage' named entity 'inflammatory response' named entity 'infection'

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