About: Retrospective clinical evaluation of four lateral flow assays for the detection of SARS-CoV-2 IgG

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Retrospective clinical evaluation of four lateral flow assays for the detection of SARS-CoV-2 IgG
Creator	Bryan, Andrew Greninger, Alexander Grys, Thomas Kaleta, Erin Grill, Francisca Lake, Douglas Mcaulay, Kathrine
Source	Elsevier; PMC
abstract	In a CLIA laboratory setting, we evaluated SARS-CoV-2 IgG detection with four lateral flow immunoassays [LFIAs; two iterations from BTNX Inc. (n = 457), and one each from ACON Laboratories (n = 200); and SD BIOSENSOR (n = 155)]. In a cohort of primarily hospitalized, RT-PCR confirmed COVID-19 cases, sensitivity at ≥14 days from symptom onset was: BTNX kit 1, 95%; BTNX kit 2, 91%; ACON, 95%; and SD, 92%. All assays showed good concordance with the Abbott SARS-CoV-2 IgG assay at ≥14 days from symptom onset: BTNX kit 1, 99%; BTNX kit 2, 94%; ACON, 99%; and SD, 100%. Specificity, measured using specimens collected prior to SARS-CoV-2 circulation in the US and “cross-reactivity challenge” specimens, was 98% for BTNX kit 1 and ACON and 100% for BTNX kit 2 and SD. These results suggest that LFIAs may provide adequate results for rapid detection of SARS-CoV-2.
has issue date	2020-08-02(xsd:dateTime)
bibo:doi	10.1016/j.diagmicrobio.2020.115161
has license	no-cc
sha1sum (hex)	9a3aabda669efd8fff57ed951e5aab6bc09c1ebe
schema:url	https://doi.org/10.1016/j.diagmicrobio.2020.115161
resource representing a document's title	Retrospective clinical evaluation of four lateral flow assays for the detection of SARS-CoV-2 IgG
has PubMed Central identifier	PMC7395943
schema:publication	Diagn Microbiol Infect Dis
resource representing a document's body	covid:9a3aabda669efd8fff57ed951e5aab6bc09c1ebe#body_text
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