About: Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity
Creator	Guo, Hongbo Peng, Wenjie Bouwman, Kim Cornelis, A De Haan, Dekkers, Jojanneke Paulson, James Van Kuppeveld, Frank Verheije, M De Vries, Erik Guo, ( Nycholat, Corwin Van Kuppeveld, F De Vries, E Dekkers, J Bouwman, K Mcbride, Ryan
Source	PMC
abstract	Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. H5N8 and H5N2 viruses have caused major economic losses in the poultry industry in Europe and North America, and lethal human infections with H5N6 virus have occurred in Asia. Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. We report that emergence of these viruses is accompanied by a change in receptor-binding specificity. In contrast to ancestral clade 2.3.4 H5 proteins, novel clade 2.3.4.4 H5 proteins bind to fucosylated sialosides because of substitutions K222Q and S227R, which are unique for highly pathogenic influenza virus H5 proteins. North American clade 2.3.4.4 virus isolates have retained only the K222Q substitution but still bind fucosylated sialosides. Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses.
has issue date	2017-02-01(xsd:dateTime)
bibo:doi	10.3201/eid2302.161072
bibo:pmid	27869615
has license	no-cc
sha1sum (hex)	9a473a8b0c6f5a6d34a3201ab9635c5973149fd5
schema:url	https://doi.org/10.3201/eid2302.161072
resource representing a document's title	Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity
has PubMed Central identifier	PMC5324792
has PubMed identifier	27869615
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:9a473a8b0c6f5a6d34a3201ab9635c5973149fd5#body_text
is schema:about of	named entity 'HIGHLY' named entity 'INFLUENZA A' named entity 'ALTERED' named entity 'PATHOGENIC' named entity 'VIRUSES' named entity 'RECEPTOR' named entity 'BINDING SPECIFICITY' named entity 'receptor binding' named entity 'H5N1' named entity 'viruses' named entity 'viruses' named entity 'H5N8' named entity 'United States' named entity 'Americas' named entity 'H5N8' named entity 'hydrogen bonds' named entity 'Asia' named entity 'culling' named entity 'H5N1' named entity 'protein' named entity 'pathogenicity' named entity 'viruses' named entity 'host range' named entity 'guide tree' named entity 'H5N1' named entity 'gisaid' named entity 'neuraminidase' named entity 'biotin' named entity 'virus' named entity 'North American' named entity 'glycan' named entity 'glycan' named entity 'H5N1' named entity 'H5N1' named entity 'trachea' named entity 'F84' named entity 'genotypes' named entity 'H5N1' named entity 'chicken' named entity 'H5N1' named entity 'H5N1' named entity 'glycan' named entity 'H5N1' named entity 'H5N8' named entity 'pathogenicity' named entity 'GISAID' named entity 'host range' named entity 'clade' named entity 'Figure 8' named entity 'binding site' named entity 'North America' named entity 'viruses' named entity 'Viruses' named entity 'glycan' named entity 'codon' named entity 'critical role' named entity 'decoy receptors' named entity 'clade' named entity 'amino acid' named entity 'binding site' named entity 'viruses' named entity 'Vietnam' named entity 'phylogenetic analysis' named entity 'virus' named entity 'H5N6'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software