About: Interferon-Independent Innate Responses to Cytomegalovirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-Independent Innate Responses to Cytomegalovirus
Creator	Belgium, Leuven, K Weyenbergh, Johan Rowland-Jones, Sarah Abendroth, Allison Ashley, Caroline Mcsharry, Brian Paludan, Soren Slobedman, Barry
Source	Medline; PMC
abstract	The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-stimulated gene (ISG) regulation in the context of CMV infection was first documented 20 years ago. Since then several IFN-independent, IRF3-dependent ISGs have been characterized and found to be among the most influential in the innate response to CMV. These include virus inhibitory protein, endoplasmic reticulum-associated IFN-inducible (viperin), ISG15, members of the interferon inducible protein with tetratricopeptide repeats (IFIT) family, interferon-inducible transmembrane (IFITM) proteins and myxovirus resistance proteins A and B (MxA, MxB). IRF3-independent, IFN-independent activation of canonically IFN-dependent signaling pathways has also been documented, such as IFN-independent biphasic activation of signal transducer and activator of transcription 1 (STAT1) during infection of monocytes, differential roles of mitochondrial and peroxisomal mitochondrial antiviral-signaling protein (MAVS), and the ability of human CMV (HCMV) immediate early protein 1 (IE1) protein to reroute IL-6 signaling and activation of STAT1 and its associated ISGs. This review examines the role of identified IFN-independent ISGs in the antiviral response to CMV and describes pathways of IFN-independent innate immune response induction by CMV.
has issue date	2019-12-11(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.02751
bibo:pmid	31921100
has license	cc-by
sha1sum (hex)	9a5373ecd01b3bcd536ed29778076947fab8eef2
schema:url	https://doi.org/10.3389/fimmu.2019.02751
resource representing a document's title	Interferon-Independent Innate Responses to Cytomegalovirus
has PubMed Central identifier	PMC6917592
has PubMed identifier	31921100
schema:publication	Front Immunol
resource representing a document's body	covid:9a5373ecd01b3bcd536ed29778076947fab8eef2#body_text
is schema:about of	named entity 'inhibitory' named entity 'gene' named entity 'transmembrane' named entity 'CMV' named entity 'CMV' named entity 'Cytomegalovirus' named entity 'MINI' named entity 'PROTEIN ' named entity 'infection' named entity 'endoplasmic' named entity 'IL-6' named entity 'This' named entity 'mediating' named entity 'ability' named entity 'response' named entity 'activation' named entity 'mitochondrial' named entity 'describes' named entity 'mitochondrial' named entity 'inducible' named entity 'differential' named entity 'infection' named entity 'protein' named entity 'CMV' named entity 'protein' named entity 'IRF3' named entity 'CMV' named entity 'virus' named entity 'infection' named entity 'endoplasmic reticulum' named entity 'IFN' named entity 'STAT1' named entity 'transmembrane' named entity 'cytomegalovirus (CMV) infection' named entity 'innate immune response' named entity 'mitochondrial' named entity 'IFN' named entity 'viperin' named entity 'signal transducer and activator of transcription' named entity 'CMV' named entity 'infection' named entity 'mitochondrial' named entity 'IFN' named entity 'Kaposi's sarcoma-associated herpesvirus' named entity 'single stranded RNA' named entity 'CMV infection' named entity 'dimerization' named entity 'nucleus' named entity 'viruses' named entity 'IRF9' named entity 'antiviral' named entity 'type I IFN' named entity 'MCMV' named entity 'IFIT1' named entity 'ISG15' named entity 'infection' named entity 'viral infection' named entity 'IRF7' named entity 'IFNα' named entity 'IFIT1' named entity 'monocyte' named entity 'adaptive immune response' named entity 'infection' named entity 'homodimers' named entity 'mitochondrial function' named entity 'GTPases' named entity 'nucleic acid' named entity 'IFN' named entity 'IFN' named entity 'MAVS' named entity 'protein' named entity 'fibroblasts' named entity 'virus'

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