About: The Tie2-agonist Vasculotide rescues mice from influenza virus infection

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About: The Tie2-agonist Vasculotide rescues mice from influenza virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Tie2-agonist Vasculotide rescues mice from influenza virus infection
Creator	Zhang, Haibo Hwang, David Leong-Poi, Howard Kuebler, Wolfgang Advani, Andrew Advani, Suzanne Armstrong, Susan Dumont, Dan Lee, Warren Sugiyama, Michael Szaszi, Katalin Tabuchi, Arata Van Slyke, Paul Wang, Changsen
Source	PMC
abstract	Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a novel therapeutic strategy with the added potential benefit of not eliciting viral resistance. Severe influenza virus infections are complicated by respiratory failure due to the development of lung microvascular leak and acute lung injury. We hypothesized that enhancing lung endothelial barrier integrity could improve the outcome. Here we demonstrate that the Tie2-agonist tetrameric peptide Vasculotide improves survival in murine models of severe influenza, even if administered as late as 72 hours after infection; the benefit was observed using three strains of the virus and two strains of mice. The effect required Tie2, was independent of viral replication and did not impair lung neutrophil recruitment. Administration of the drug decreased lung edema, arterial hypoxemia and lung endothelial apoptosis; importantly, Vasculotide is inexpensive to produce, is chemically stable and is unrelated to any Tie2 ligands. Thus, Vasculotide may represent a novel and practical therapy for severe infections with influenza.
has issue date	2015-06-05(xsd:dateTime)
bibo:doi	10.1038/srep11030
bibo:pmid	26046800
has license	cc-by
sha1sum (hex)	9a5c1b3f9b311116c99c50ecb181a2e3c71731b4
schema:url	https://doi.org/10.1038/srep11030
resource representing a document's title	The Tie2-agonist Vasculotide rescues mice from influenza virus infection
has PubMed Central identifier	PMC4457136
has PubMed identifier	26046800
schema:publication	Sci Rep
resource representing a document's body	covid:9a5c1b3f9b311116c99c50ecb181a2e3c71731b4#body_text
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