About: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset

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About: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset
Creator	Azoulay, Elie Darmon, Michael Voiriot, Guillaume Vieillard-Baron, Antoine Fartoukh, Muriel Demoule, Alexandre Géri, Guillaume Beurton, Alexandra Dres, Martin Dupont, Thibault Girodias, Lola Labbé, Vincent Zafrani, Lara
Source	Medline; PMC
abstract	PURPOSE: Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival. METHODS: In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality. RESULTS: Median age was 66 years (53–68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6–11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22–31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. Patients admitted within the first week had higher SOFA scores, more often had thrombocytopenia or acute kidney injury, had more limited radiographic involvement, and had significantly higher blood IL-6 levels. Age, COPD, immunocompromised status, time from disease onset, troponin concentration, and acute kidney injury were independently associated with mortality. CONCLUSION: The excess mortality in patients admitted within a week of disease onset reflected greater non-respiratory severity. Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06202-3) contains supplementary material, which is available to authorized users.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.1007/s00134-020-06202-3
bibo:pmid	32780165
has license	no-cc
sha1sum (hex)	9a6c27dfb687bd031dad4a38710bba0534e58c27
schema:url	https://doi.org/10.1007/s00134-020-06202-3
resource representing a document's title	Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset
has PubMed Central identifier	PMC7417780
has PubMed identifier	32780165
schema:publication	Intensive Care Med
resource representing a document's body	covid:9a6c27dfb687bd031dad4a38710bba0534e58c27#body_text
is schema:about of	named entity 'patients' covid:arg/9a6c27dfb687bd031dad4a38710bba0534e58c27 named entity 'intensive care unit (ICU)' named entity 'creating' named entity 'survival' named entity 'Coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'ICU' named entity 'SARS-CoV-2' named entity 'RT-PCR' named entity 'Dyspnoea' named entity 'chemokine' named entity 'symptom' named entity 'Wuhan' named entity 'organ dysfunction' named entity 'morbidity' named entity 'genome' named entity 'dyspnoea' named entity 'symptom' named entity 'virus' named entity 'eicosanoids' named entity 'apoptotic' named entity 'COVID-19' named entity 'infection' named entity 'diarrhoea' named entity 'ICU' named entity 'ICU' named entity 'SARS-CoV-2' named entity 'refractory' named entity 'ICU' named entity 'bacterial infection' named entity 'kidney' named entity 'excess mortality' named entity 'Kaplan-Meier' named entity 'incubation period' named entity 'inflammation' named entity 'critically ill' named entity 'COVID' named entity 'hypertension' named entity 'symptom' named entity 'acute kidney injury' named entity 'acute kidney injury' named entity 'lung' named entity 'variable selection' named entity 'interquartile range' named entity 'cough' named entity 'ICU' named entity 'immunosuppressive therapy' named entity 'lung' named entity 'COVID' named entity 'standard of care' named entity 'intensivists' named entity 'troponin' named entity 'critical illness' named entity 'cytokines' named entity 'immunosuppression' named entity 'heart failure' named entity 'renal replacement therapy' named entity 'epithelial' named entity 'runny nose' named entity 'immunosuppressant' named entity 'ethics committee' named entity 'log-rank test' named entity 'antiviral' named entity 'acute kidney injury' named entity 'exudative' named entity 'IL6' named entity 'mortality rate' named entity 'general practitioner'

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