About: Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

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About: Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses
Creator	Farzan, Michael Choe, Hyeryun Jemielity, Stephanie Abraham, Jonathan Radoshitzky, Sheli
Source	Elsevier; Medline; PMC
abstract	At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor. Accidental similarities between human TfR1 and TfR1 orthologs of arenviral host species enable zoonoses, whereas mice and rats are not infectable because they lack these TfR1 determinants of infection. All pathogenic New World arenaviruses bind to a common region of the apical domain of TfR1. The ability of a New World arenavirus to use human TfR1 is absolutely predictive of its ability to cause hemorrhagic fevers in humans. Non-pathogenic arenaviruses, closely related to hemorrhagic fever arenaviruses, cannot utilize human TfR1 but efficiently enter cells through TfR1 orthologs of their native rodent hosts. Mutagenesis studies suggest that minor changes in the entry glycoproteins of these non-pathogenic viruses may allow human transmission. TfR1 is upregulated as a result of iron sequestration during the acute phase response to infection, and the severity of disease may result from amplification of viral replication during this response.
has issue date	2011-08-01(xsd:dateTime)
bibo:doi	10.1016/j.mib.2011.07.014
bibo:pmid	21807555
has license	green-oa
sha1sum (hex)	9a7d7a25d797132cd676fa07da4c262333d340e3
schema:url	https://doi.org/10.1016/j.mib.2011.07.014
resource representing a document's title	Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses
has PubMed Central identifier	PMC3159852
has PubMed identifier	21807555
schema:publication	Current Opinion in Microbiology
resource representing a document's body	covid:9a7d7a25d797132cd676fa07da4c262333d340e3#body_text
is schema:about of	named entity 'ARENAVIRUSES' named entity 'THEIR' named entity 'TRANSMISSION' named entity 'SEVERE' named entity 'ALLOW' named entity 'TFR1' named entity 'THESE' named entity 'HOST SPECIES' named entity 'ENABLE' named entity 'SEVERITY' named entity 'STUDIES' named entity 'REGION' named entity 'CONTACT WITH' named entity 'PREDICTIVE' named entity 'absolutely' named entity 'orthologs' named entity 'sequestration' named entity 'similarities' named entity 'iron' named entity 'HEMORRHAGIC FEVER' named entity 'RELATED' named entity 'NEW' covid:arg/9a7d7a25d797132cd676fa07da4c262333d340e3 named entity 'WORLD' named entity 'ZOONOSIS' named entity 'HEMORRHAGIC FEVERS' named entity 'NON-' named entity 'VIRUSES' named entity 'SOUTH AMERICAN' named entity 'USE' named entity 'TRANSFERRIN RECEPTOR 1' named entity 'PATHOGENIC' named entity 'AMPLIFICATION' named entity 'HEMORRHAGIC FEVER' named entity 'RATS' named entity 'RESPONSE' named entity 'ABILITY' named entity 'AS A RESULT OF' named entity 'CHANGES' named entity 'TRANSMITTED' named entity 'NATIVE' named entity 'ENTER' named entity 'HUMAN' named entity 'GLYCOPROTEINS' named entity 'VIRAL REPLICATION' named entity 'UPREGULATED' named entity 'MINOR' named entity 'BUT' named entity 'DOMAIN' named entity 'IRON' named entity 'RESPONSE TO' named entity 'ARENAVIRUSES' named entity 'ITS' named entity 'ZOONOSES' named entity 'APICAL' named entity 'SEQUESTRATION' named entity 'PATHOGENESIS' named entity 'TRANSFERRIN RECEPTOR 1' named entity 'LACK' named entity 'ACCIDENTAL' named entity 'SUGGEST' named entity 'BIND' named entity 'RODENT' named entity 'A COMMON' named entity 'USES' named entity 'NEW WORLD ARENAVIRUS' named entity 'HUMANS' named entity 'DETERMINANTS' named entity 'INFECTION' named entity 'NEW WORLD ARENAVIRUSES' named entity 'RESULT' named entity 'CELLS' named entity 'RECEPTOR' named entity 'OBLIGATE' named entity 'CAUSE' named entity 'ENTRY' named entity 'ACUTE PHASE RESPONSE'

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