About: New clinical and seasonal evidence of infections by Human Parainfluenzavirus

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About: New clinical and seasonal evidence of infections by Human Parainfluenzavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New clinical and seasonal evidence of infections by Human Parainfluenzavirus
Creator	Melón García, Santiago Antonio, José Riveiro, Boga Agustina, María De Oña Navarro, María De, María Es, García Leal, Álvaro Melón, Santiago Navarro, Oña Pérez Martínez, Zulema Rodríguez Súarez, Julián Rojo-Alba, Susana
Source	Medline; PMC
abstract	Human Parainfluenzaviruses (PIVs) account for a significant proportion of viral acute respiratory infections (ARIs) in children, and are also associated with morbidity and mortality in adults, including nosocomial infections. This work aims to describe PIV genotypes and their clinical and epidemiological distribution. Between December 2016 and December 2017, 6121 samples were collected, and submitted to viral culture and genomic quantification, specifically Parainfluenza 1–4 (PIV1–4), Influenza A and B, Respiratory Syncytial Virus (RSV) A and B, Adenovirus, Metapneumovirus, Coronavirus, Rhinovirus, and Enterovirus. Normalized viral load, as (log10) copies/10(3) cells, was calculated as virus Ct, determined by multiple qRT-PCR, as a function of the Ct of β-globin. PIV was confirmed in 268 cases (4.37%), and linked to both upper and lower respiratory tract disease, being more frequent in children than in adults (5.23 and 2.43%, respectively). PIV1 and PIV3 were most common (31 and 32.5%, of total PIV positive samples, respectively), with distribution being similar in children and adults, as was viral load. PIV type was correlated with seasonality: PIV3 being more frequent in winter and spring, PIV1 in summer, and PIV 4 in fall. No correlation between vial load and clinical severity was found. Novel findings were that PIV viral load was higher in fall than in other seasons, and PIV4, classically linked to mild respiratory symptoms, was circulating, in children and adults, at all levels of symptoms throughout the year.
has issue date	2018-08-24(xsd:dateTime)
bibo:doi	10.1007/s10096-018-3363-y
bibo:pmid	30143939
has license	no-cc
sha1sum (hex)	9a99b1dc5bb5a670c56cfd7c55d3777475fdf260
schema:url	https://doi.org/10.1007/s10096-018-3363-y
resource representing a document's title	New clinical and seasonal evidence of infections by Human Parainfluenzavirus
has PubMed Central identifier	PMC7088353
has PubMed identifier	30143939
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:9a99b1dc5bb5a670c56cfd7c55d3777475fdf260#body_text
is schema:about of	named entity 'NEW' named entity 'Coronavirus' named entity 'adults' named entity 'confirmed' named entity 'SAMPLES' named entity 'HIGHER' named entity 'SEVERITY' named entity 'FUNCTION' named entity 'NOVEL' named entity 'CELLS' named entity '268' named entity 'ADULTS' covid:arg/9a99b1dc5bb5a670c56cfd7c55d3777475fdf260 named entity 'COMMON' named entity 'MILD' named entity 'LOWER RESPIRATORY TRACT DISEASE' named entity 'BEING' named entity 'FOUND' named entity 'CASES' named entity 'CONFIRMED' named entity 'SIGNIFICANT' named entity 'SYMPTOMS' named entity 'SPRING' named entity 'UPPER' named entity 'ACCOUNT' named entity 'NOSOCOMIAL INFECTIONS' named entity 'VIAL' named entity 'SEASONALITY' named entity 'CLINICAL' named entity 'YEAR' named entity 'SUMMER' named entity 'HUMAN' named entity 'PARAINFLUENZAVIRUS' named entity 'CHILDREN' named entity 'EPIDEMIOLOGICAL' named entity 'WORK' named entity 'CLINICAL' named entity 'GENOMIC' named entity 'VIRAL' named entity 'EVIDENCE OF' named entity 'LEVELS' named entity 'CORRELATION' named entity 'QUANTIFICATION' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity 'DECEMBER' named entity 'GENOTYPES' named entity 'METAPNEUMOVIRUS' named entity 'CALCULATED' named entity 'AIMS' named entity 'NORMALIZED' named entity 'ASSOCIATED WITH' named entity 'COLLECTED' named entity 'PIV3' named entity 'SUBMITTED' named entity 'SEASONS' named entity 'GLOBIN' named entity 'AS VIRUS' named entity 'PROPORTION' named entity '32.5' named entity 'SIMILAR' named entity 'FALL' named entity 'QRT-PCR' named entity 'VIRAL LOAD' named entity 'TO DESCRIBE' named entity 'FREQUENT' named entity 'WITH DISTRIBUTION' named entity 'MULTIPLE' named entity 'THEIR' named entity 'SEASONAL'

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