About: The Evolutionary History and Spatiotemporal Dynamics of the Fever, Thrombocytopenia and Leukocytopenia Syndrome Virus (FTLSV) in China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Evolutionary History and Spatiotemporal Dynamics of the Fever, Thrombocytopenia and Leukocytopenia Syndrome Virus (FTLSV) in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Evolutionary History and Spatiotemporal Dynamics of the Fever, Thrombocytopenia and Leukocytopenia Syndrome Virus (FTLSV) in China
Creator	Chen, Weijun Du, Yanhua Huang, Xueyong Liu, Licheng Tang, Xiaoyan Wang, Haifeng Wu, Weili Xu, Bianli Yang, Yinhui Jiang, Yongqiang Liu, Qi Su, Jia
Source	PMC
abstract	BACKGROUND: In 2007, a novel bunyavirus was found in Henan Province, China and named fever, thrombocytopenia and leukocytopenia syndrome virus (FTLSV); since then, FTLSV has been found in ticks and animals in many Chinese provinces. Human-to-human transmission has been documented, indicating that FTLSV should be considered a potential public health threat. Determining the historical spread of FTLSV could help curtail its spread and prevent future movement of this virus. METHOD/PRINCIPAL FINDINGS: To examine the pattern of FTLSV evolution and the origin of outbreak strains, as well to examine the rate of evolution, the genome of 12 FTLSV strains were sequenced and a phylogenetic and Bayesian phylogeographic analysis of all available FTLSV sequences in China were performed. Analysis based on the FTLSV L segment suggests that the virus likely originated somewhere in Huaiyangshan circa 1790 (95% highest probability density interval: 1756–1817) and began spreading around 1806 (95% highest probability density interval: 1773–1834). Analysis also indicates that when FTLSV arrived in Jiangsu province from Huaiyangshan, Jiangsu Province became another source for the spread of the disease. Bayesian factor test analysis identified three major transmission routes: Huaiyangshan to Jiangsu, Jiangsu to Liaoning, and Jiangsu to Shandong. The speed of FTLSV movement has increased in recent decades, likely facilitated by modern human activity and ecosystem changes. In addition, evidence of RNA segment reassortment was found in FTLSV; purifying selection appears to have been the dominant force in the evolution of this virus. CONCLUSION: Results presented in the manuscript suggest that the Huaiyangshan area is likely be the origin of FTLSV in China and identified probable viral migration routes. These results provide new insights into the origin and spread of FTLSV in China, and provide a foundation for future virological surveillance and control.
has issue date	2014-10-16(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0003237
bibo:pmid	25329580
has license	cc-by
sha1sum (hex)	9b1b665e6ea27f485898427a23df51c18ed0ebb7
schema:url	https://doi.org/10.1371/journal.pntd.0003237
resource representing a document's title	The Evolutionary History and Spatiotemporal Dynamics of the Fever, Thrombocytopenia and Leukocytopenia Syndrome Virus (FTLSV) in China
has PubMed Central identifier	PMC4199521
has PubMed identifier	25329580
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:9b1b665e6ea27f485898427a23df51c18ed0ebb7#body_text
is schema:about of	named entity 'indicating' named entity 'SYNDROME' named entity 'PUBLIC HEALTH' named entity 'BUNYAVIRUS' named entity 'BACKGROUND' named entity 'TICKS' named entity 'FOUND' named entity 'HUMAN' named entity 'TRANSMISSION' named entity 'INDICATING' named entity 'ticks' named entity '2007' named entity 'thrombocytopenia' named entity 'Henan Province' named entity 'virus' named entity 'public health' named entity 'ticks' named entity 'leukocytopenia' named entity 'Anhui' named entity 'highest posterior density' named entity 'vectors' named entity 'Jiangsu' named entity 'thrombocytopenia' named entity 'phylogenetic' named entity 'Jiangsu' named entity 'virus' named entity 'virus' named entity 'Jiangsu' named entity 'vectors' named entity 'China' named entity 'influenza virus' named entity 'nucleotides' named entity 'Shandong' named entity 'Serum samples' named entity 'leukopenia' named entity 'Phlebovirus' named entity 'genus' named entity 'public health' named entity 'RNA-dependent RNA polymerase' named entity 'genotypes' named entity 'viral transmission' named entity 'Henan Province' named entity 'Uukuniemi virus' named entity 'Haemaphysalis longicornis' named entity 'China' named entity 'Rhipicephalus microplus' named entity 'nucleotide substitutions' named entity 'myalgia' named entity 'pathogen' named entity 'Phylogenetic analysis' named entity 'evolution' named entity 'SLAC' named entity 'measles' named entity 'pathogenicity' named entity 'Phylogenetic trees' named entity 'virus' named entity 'Huaihe River' named entity 'viral RNA' named entity 'dN/dS' named entity 'Center for Disease Control and Prevention' named entity 'spatiotemporal pattern' named entity 'Rhipicephalus microplus' named entity 'recombination' named entity 'China' named entity 'protein synthesis' named entity 'Haemaphysalis longicornis' named entity 'purifying selection' named entity 'purifying selection' named entity 'GenBank' named entity 'China'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software