About: Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study

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About: Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study
Creator	Cohen, Avivit Gorohovski, Alessandro Green, Ilan Merzon, Eugene Morgenstern, Milana Tworowski, Dmitry Vinker, Shlomo
Source	Medline; PMC
abstract	AIM: To evaluate associations of plasma 25(OH)D status with the likelihood of coronavirus disease (COVID‐19) infection and hospitalization. METHODS: The study population included the 14,000 members of Leumit Health Services who were tested for COVID‐19 infection from February 1(st) to April 30(th) 2020, and who had at least one previous blood test for plasma 25(OH)D level. %22Suboptimal%22 or %22low%22 plasma 25(OH)D level was defined as plasma 25‐hydroxyvitamin D, or 25(OH)D, concentration below the level of 30 ng/mL. RESULTS: Of 7,807 individuals, 782 (10.1%) were COVID‐19‐positive, and 7,025 (89.9%) COVID‐19‐negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID‐19 [19.00 ng/mL (95% confidence interval [CI] 18.41‐19.59) vs. 20.55 (95% CI 20.32‐20.78)]. Univariate analysis demonstrated an association between low plasma 25(OH)D level and increased likelihood of COVID‐19 infection [crude odds ratio (OR) of 1.58 (95% CI 1.24‐2.01, p<0.001)], and of hospitalization due to the SARS‐CoV‐2 virus [crude OR of 2.09 (95% CI 1.01‐ 4.30, p<0.05)]. In multivariate analyses that controlled for demographic variables, and psychiatric and somatic disorders, the adjusted OR of COVID‐19 infection [1.45 (95% CI 1.08‐1.95, p<0.001)], and of hospitalization due to the SARS‐CoV‐2 virus [1.95 (95% CI 0.98‐4.845, p=0.061)] were preserved. In the multivariate analyses, age over 50 years, male gender and low‐medium socioeconomic status were also positively associated with the risk of COVID‐19 infection; age over 50 years was positively associated with the likelihood of hospitalization due to COVID‐19. CONCLUSION: Low plasma 25(OH)D level appears to be an independent risk factor for COVID‐19 infection and hospitalization.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1111/febs.15495
bibo:pmid	32700398
has license	no-cc
sha1sum (hex)	9b2188fd808475e785fd51578bf8bc4c417c29dc
schema:url	https://doi.org/10.1111/febs.15495
resource representing a document's title	Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study
has PubMed Central identifier	PMC7404739
has PubMed identifier	32700398
schema:publication	FEBS J
resource representing a document's body	covid:9b2188fd808475e785fd51578bf8bc4c417c29dc#body_text
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