About: Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers
Creator	Tyrrell, D Callow, Katheeen Eitzharris, Penny Kay, A Shaw, Wardlaw, A
source	Medline; PMC
abstract	In an attempt to understand the relationship between viral upper respiratory tract infection and the underlying virological and immunological mechanisms, thirty‐four volunteers were inoculated intranasally with coronavirus 229E; subsequent virus shedding and/or antibody rises, indicating active infection, were observed in twenty‐nine. There was a greater increase in independently measured scores of clinical severity, e.g. cold symptoms, in those with detectable IgE in nasal secretions (P < 0.01). A similar association was found between clinical scores and serum IgE concentrations 150 IU/ml, but the relationship with systemic atopy, as assessed by skin‐prick tests to common allergens, was less marked. A more detailed study of twelve of the infected volunteers failed to explain these findings on the basis of mast ceil mediator release, as concentrations of leukotriene B(4), the sulphidopeptide leukotriene C(4), and histamine, were not appreciably elevated in the nasal secretions following virus inoculation. Similarly, there was no evidence that circulating coronavirus specific IgE was produced. Thus, this study suggests that atopy may be related to the severity of cold symptoms produced by coronavirus 229E, although the exact connection has yet to be determined.
has issue date	2006-04-27(xsd:dateTime)
bibo:doi	10.1111/j.1365-2222.1988.tb02851.x
bibo:pmid	2835193
has license	no-cc
sha1sum (hex)	9b21ef3b53ab2efe26c216a605979f670d4129b5
schema:url	https://doi.org/10.1111/j.1365-2222.1988.tb02851.x
resource representing a document's title	Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers
has PubMed Central identifier	PMC7194196
has PubMed identifier	2835193
schema:publication	Clin Exp Allergy
resource representing a document's body	covid:9b21ef3b53ab2efe26c216a605979f670d4129b5#body_text
is schema:about of	named entity 'infected' named entity 'IgE' named entity 'specific' named entity 'intranasally' named entity 'infection' named entity 'adult' named entity 'serum' named entity 'cold' named entity 'mechanisms' named entity 'atopy' named entity 'immunological' named entity 'antibody' named entity 'cold' named entity 'nasal secretions' named entity 'virological' named entity 'antibody' named entity 'atopy' named entity 'viral upper respiratory tract infection' named entity 'serum' named entity 'IgE' named entity 'methyl' named entity 'infection' named entity '229E' named entity 'virus infection' named entity 'Personal Computers' named entity 'statistically significant' named entity 'virus' named entity 'IgE' named entity 'histamine' named entity 'NEN' named entity 'IgE' named entity 'methyl' named entity 'Watford' named entity 'total protein' named entity 'Uppsala' named entity 'IgE' named entity 'virus' named entity 'IgE' named entity 'allergens' named entity 'Pharmacia' named entity 'antigen' named entity 'humoral' named entity 'serum' named entity 'atopy' named entity 'histamine' named entity 'infection' named entity 'antigen' named entity 'supernatant' named entity 'bovine serum albumin' named entity 'standard curve' named entity 'antiserum' named entity '229E' named entity 'asthmatic' named entity 'histamine' named entity 'common pathway' named entity 'Merck' named entity 'statistically significant' named entity 'centrifugation' named entity 'centrifuged' named entity 'optical density' named entity 'leukotriene' named entity 'alkaline phosphatase' named entity 'Histamine' named entity 'statistically significant' named entity 'viral infection' named entity 'atopy' named entity 'IgE' named entity 'skin-prick' named entity 'rhinovirus' named entity 'standard curve' named entity 'infection' named entity 'serum' named entity 'atopy' named entity 'BSA' named entity 'IgE' named entity 'allergic rhinitis'

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