About: Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation
Creator	Soe, Y Sun, L Lim, W Chia, W Hee, S Leong, S Phoon, Y Tai, W Tan, E Tan, S Thng, C Toh, H Yap, S
Source	Medline; PMC
abstract	While nonmyeloablative peripheral blood stem cell transplantation (NST) has shown efficacy against several solid tumors, it is untested in nasopharyngeal cancer (NPC). In a phase II clinical trial, 21 patients with pretreated metastatic NPC underwent NST with sibling PBSC allografts, using CY conditioning, thymic irradiation and in vivo T-cell depletion with thymoglobulin. Stable lymphohematopoietic chimerism was achieved in most patients and prophylactic CYA was tapered at a median of day +30. Seven patients (33%) showed partial response and three (14%) achieved stable disease. Four patients were alive at 2 years and three showed prolonged disease control of 344, 525 and 550 days. With a median follow-up of 209 (4–1147) days, the median PFS was 100 days (95% confidence interval (CI), 66–128 days), and median OS was 209 days (95% CI, 128–236 days). Patients with chronic GVHD had better survival—median OS 426 days (95% CI, 194–NE days) vs 143 days (95% CI, 114–226 days) (P=0.010). Thus, NST may induce meaningful clinical responses in patients with advanced NPC.
has issue date	2010-07-26(xsd:dateTime)
bibo:doi	10.1038/bmt.2010.161
bibo:pmid	20661236
has license	cc-by-nc-nd
sha1sum (hex)	9b49622e8c16b0e941616d09e9ccdcfbc5d5ff0c
schema:url	https://doi.org/10.1038/bmt.2010.161
resource representing a document's title	Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation
has PubMed Central identifier	PMC3072519
has PubMed identifier	20661236
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:9b49622e8c16b0e941616d09e9ccdcfbc5d5ff0c#body_text
is schema:about of	named entity '100 days' named entity 'patients' named entity 'Patients' named entity 'patients' named entity 'conditioning' named entity 'confidence interval' named entity 'alive' named entity 'patients' named entity 'advanced' named entity 'TRANSPLANTATION' named entity '28P' named entity 'PROLONGED' named entity 'T-CELL DEPLETION' named entity 'NPC' named entity 'SEVEN' named entity 'CLINICAL' named entity 'INDUCE' named entity 'ADVANCED' named entity 'SOLID TUMORS' named entity 'STABLE' named entity 'DISEASE CONTROL' named entity 'SURVIVAL' named entity '010' named entity 'FOLLOW-UP' named entity 'THYMOGLOBULIN' named entity 'PERIPHERAL BLOOD STEM CELL TRANSPLANTATION' named entity 'TREATED WITH' named entity 'ADVANCED' named entity 'ALLOGENEIC' named entity 'PBSC' named entity 'NASOPHARYNGEAL CANCER' named entity 'PATIENTS' named entity 'EFFECT' named entity 'ALLOGRAFTS' named entity 'THYMIC' named entity 'NASOPHARYNGEAL CANCER' named entity 'TUMOR' named entity 'GRAFT' named entity 'ALIVE' named entity 'PARTIAL RESPONSE' named entity 'IRRADIATION' named entity 'CONFIDENCE INTERVAL' named entity 'STABLE DISEASE' named entity 'DAYS' named entity '114' named entity 'CYA' named entity 'PATIENTS' named entity 'EFFICACY' named entity 'CHIMERISM' named entity 'IN VIVO' named entity 'PBSC' named entity 'RESPONSES' named entity 'YEARS' named entity 'PHASE II CLINICAL TRIAL' named entity 'METASTATIC' named entity '550' named entity 'DAY' named entity 'TAPERED' named entity 'BETTER' named entity '143' named entity '100' named entity 'CHRONIC GVHD' named entity '426' named entity 'NST' named entity '525' named entity 'PFS' named entity 'CONDITIONING' named entity 'MEDIAN' named entity 'USING'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software