About: Comprehensive mapping of immune perturbations associated with severe COVID-19

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About: Comprehensive mapping of immune perturbations associated with severe COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comprehensive mapping of immune perturbations associated with severe COVID-19
Creator	Gouma, Sigrid Betts, Michael Meyer, Nuala Hensley, Scott Wherry, E Agyekum, Roseline Anderson, Elizabeth Apostolidis, Sokratis Arevalo, Claudia Baxter, Amy Bershaw, Luanne Bolton, Marcus Dougherty, Jeanette Goodwin, Eileen Greenplate, Allison Han, Nicholas Ittner, Caroline Jones, Tiffanie Kim, Justin Kuri-Cervantes, Leticia Kuthuru, Oliva Mangalmurti, Nilam Mathew, Divij Meng, Wenzhao Pattekar, Ajinkya Rosenfeld, Aaron Vella, Laura Weirick, Madison Weisman, Ariel Betina Pampena, M Prak, Eline
Source	Medline; PMC
abstract	Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1126/sciimmunol.abd7114
bibo:pmid	32669287
has license	cc-by
sha1sum (hex)	9b50a952b29e7dd2b7cb5ea784b76fe1b028c162
schema:url	https://doi.org/10.1126/sciimmunol.abd7114
resource representing a document's title	Comprehensive mapping of immune perturbations associated with severe COVID-19
has PubMed Central identifier	PMC7402634
has PubMed identifier	32669287
schema:publication	Sci Immunol
resource representing a document's body	covid:9b50a952b29e7dd2b7cb5ea784b76fe1b028c162#body_text
is schema:about of	named entity 'granulocytes' named entity 'ratio' named entity 'ANALYZED' named entity 'HOST' named entity 'SEVERE SARS-COV-2 INFECTION' named entity 'IDENTIFIED' named entity 'INDUCED' named entity 'activation' named entity 'COVID-19' named entity 'correlates' named entity 'induced' named entity 'therapeutic' named entity 'T cell' named entity 'COVID-19' named entity 'disease' named entity 'severe' named entity 'extensive' named entity 'biomarker' named entity 'plasmablast' named entity 'COVID' named entity 'perturbations' named entity 'interstitial lung disease' named entity 'PMN' named entity 'COVID' named entity 'amino acid sequences' named entity 'clones' named entity 'cell types' named entity 'chronic inflammatory conditions' named entity 'CD4+' named entity 'CD16' named entity 'ferritin' named entity 'NK cell' named entity 'IgG' named entity 'cytotoxic' named entity 'lymphopenia' named entity 'CD16' named entity 'clinical characteristics' named entity 'COVID-19' named entity 'clinical care' named entity 'neutrophils' named entity '2, 3' named entity 'COVID' named entity 'COVID-19' named entity 'clonal' named entity 'CD27' named entity 'NLR' named entity 'COVID-19 disease' named entity 'antibody' named entity 'multi-organ failure' named entity 'inflammation' named entity 'antibodies'

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