About: Ovarian Tumor (OTU)-domain Containing Viral Proteases Evade Ubiquitin- and ISG15-dependent Innate Immune Responses

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About: Ovarian Tumor (OTU)-domain Containing Viral Proteases Evade Ubiquitin- and ISG15-dependent Innate Immune Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ovarian Tumor (OTU)-domain Containing Viral Proteases Evade Ubiquitin- and ISG15-dependent Innate Immune Responses
Creator	Kikkert, Marjolein Schmaljohn, Connie Paragas, Jason García-Sastre, Adolfo Frias-Staheli, Natalia Bridgen, Anne Snijder, Eric Lenschow, Deborah Richt, Juergen Rowland, Raymond Taylor, Shannon Giannakopoulos, Nadia Iv, Virgin Whiting, Herbert
Source	Elsevier; Medline; PMC
abstract	Ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) reversibly conjugate to proteins via a conserved LRLRGG C-terminal motif, mediating important innate antiviral responses. The ovarian tumor (OTU) domain represents a superfamily of predicted proteases found in eukaryotic, bacterial and viral proteins, some of which have Ub-deconjugating activity. We show that the OTU domain-containing proteases of nairoviruses and arteriviruses hydrolyze Ub and ISG15 from cellular target proteins. This broad activity contrasts with the target specificity of known mammalian OTU domain-containing proteins. The biological significance of this activity of viral OTU domain-containing proteases was evidenced by their capacity to inhibit NF-κB dependent signaling and to antagonize the antiviral effects of ISG15 during Sindbis virus infection in vivo. The deconjugating activity of viral OTU proteases represents a novel viral immune evasion mechanism that inhibits Ub-and ISG15-dependent antiviral pathways.
has issue date	2007-12-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2007.09.014
bibo:pmid	18078692
has license	green-oa
sha1sum (hex)	9ba047a759c291bd690dd1ab2ba190525733a624
schema:url	https://doi.org/10.1016/j.chom.2007.09.014
resource representing a document's title	Ovarian Tumor (OTU)-domain Containing Viral Proteases Evade Ubiquitin- and ISG15-dependent Innate Immune Responses
has PubMed Central identifier	PMC2184509
has PubMed identifier	18078692
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:9ba047a759c291bd690dd1ab2ba190525733a624#body_text
is schema:about of	named entity 'PROTEASES' named entity 'cDNAs' named entity 'N-terminal' named entity 'parallel' named entity 'assembled' named entity 'strategy' named entity 'Viral' named entity 'OVARIAN TUMOR' named entity 'CHICKEN' named entity 'DATA' named entity 'PARALLEL' named entity 'UNIVERSITY' named entity 'MADISON' named entity 'BACTERIA ' named entity 'ULSTER' named entity 'DOMAIN' named entity 'MULTIPLE' named entity 'UNPUBLISHED' named entity 'SEQUENCES' named entity 'GENERATED' named entity 'COMPLETE' named entity 'TICKS' named entity 'MODIFIED' named entity '27S' named entity 'OBTAINED BY' named entity 'GENERATING' named entity 'CLONED' named entity 'ACTIN' named entity 'PCR' named entity 'OTU' named entity 'RT-PCR' named entity 'LENGTH' named entity 'HYALOMMA EXCAVATUM' named entity 'DEPENDENT' named entity 'UNITED STATES' named entity 'VIRAL RNA' named entity 'REVERSE TRANSCRIPTION' named entity 'FRAGMENTS' named entity 'DOMAIN' named entity 'TRANSCRIPTS' named entity 'NIGERIA' named entity 'SITES' named entity 'ISOLATED' named entity 'TAGGED' named entity 'ISG15' named entity 'SUPPLEMENTAL' named entity 'CONTAINING' named entity 'DATA' named entity 'UBIQUITIN' named entity 'IMMUNE RESPONSES' named entity 'VIRAL' named entity 'C-TERMINAL' named entity 'CONTROL' named entity 'TRANSFERRED TO' named entity 'VIRAL PROTEIN' named entity 'RNA' named entity 'TRIZOL' named entity 'PLASMID' named entity 'ORDER' named entity 'INTRODUCED' named entity 'INTRODUCED INTO' named entity 'PROMOTER' named entity 'STRATEGY' named entity 'PROTOCOL' named entity 'USING' named entity 'N-TERMINAL ' named entity 'EXPRESSION' named entity 'ENDS'

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