About: Multiple Sclerosis: The Role of Cytokines in Pathogenesis and in Therapies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple Sclerosis: The Role of Cytokines in Pathogenesis and in Therapies
Creator	Amedei, Amedeo Prisco, Domenico Milco D'elios, Mario
topic	covid:9bbac1f67fbab1d4f3e9a20387a63989bf40bfad#this
Source	Medline; PMC
abstract	Multiple sclerosis, the clinical features and pathological correlate for which were first described by Charcot, is a chronic neuroinflammatory disease with unknown etiology and variable clinical evolution. Although neuroinflammation is a descriptive denominator in multiple sclerosis based on histopathological observations, namely the penetration of leukocytes into the central nervous system, the clinical symptoms of relapses, remissions and progressive paralysis are the result of losses of myelin and neurons. In the absence of etiological factors as targets for prevention and therapy, the definition of molecular mechanisms that form the basis of inflammation, demyelination and toxicity for neurons have led to a number of treatments that slow down disease progression in specific patient cohorts, but that do not cure the disease. Current therapies are directed to block the immune processes, both innate and adaptive, that are associated with multiple sclerosis. In this review, we analyze the role of cytokines in the multiple sclerosis pathogenesis and current/future use of them in treatments of multiple sclerosis.
has issue date	2012-10-19(xsd:dateTime)
bibo:doi	10.3390/ijms131013438
bibo:pmid	23202961
has license	cc-by
sha1sum (hex)	9bbac1f67fbab1d4f3e9a20387a63989bf40bfad
schema:url	https://doi.org/10.3390/ijms131013438
resource representing a document's title	Multiple Sclerosis: The Role of Cytokines in Pathogenesis and in Therapies
has PubMed Central identifier	PMC3497335
has PubMed identifier	23202961
schema:publication	Int J Mol Sci
resource representing a document's body	covid:9bbac1f67fbab1d4f3e9a20387a63989bf40bfad#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9bbac1f67fbab1d4f3e9a20387a63989bf40bfad
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