About: Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity

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About: Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity
Creator	Fang, Liurong Wang, Dang Xiao, Shaobo Peng, Guiqing Zhu, Xinyu Fang, Puxian Hong, Yingying Liu, Xiaorong
topic	covid:9bbcdc1db7feeedcd55ba7f4e429f2c8358b4221#this
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus causing diarrhea and intestinal damage in nursing piglets. Previous work showed that PDCoV infection inhibits type I interferon (IFN) production. To further identify and characterize the PDCoV-encoded IFN antagonists will broaden our understanding of its pathogenesis. Nonstructural protein 15 (nsp15) encodes an endoribonuclease that is highly conserved among vertebrate nidoviruses (coronaviruses and arteriviruses) and plays a critical role in viral replication and transcription. Here, we found that PDCoV nsp15 significantly inhibits Sendai virus (SEV)-induced IFN-β production. PDCoV nsp15 disrupts the phosphorylation and nuclear translocation of NF-κB p65 subunit, but not antagonizes the activation of transcription factor IRF3. Interestingly, site-directed mutagenesis found that PDCoV nsp15 mutants (H129A, H234A, K269A) lacking endoribonuclease activity also suppress SEV-induced IFN-β production and NF-κB activation, suggesting that the endoribonuclease activity is not required for its ability to antagonize IFN-β production. Taken together, our results demonstrate that PDCoV nsp15 is an IFN antagonist and it inhibits interferon-β production via an endoribonuclease activity-independent mechanism.
has issue date	2019-10-31(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2019.07.003
bibo:pmid	31351410
has license	els-covid
sha1sum (hex)	9bbcdc1db7feeedcd55ba7f4e429f2c8358b4221
schema:url	https://doi.org/10.1016/j.molimm.2019.07.003
resource representing a document's title	Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity
has PubMed Central identifier	PMC7112593
has PubMed identifier	31351410
schema:publication	Molecular Immunology
resource representing a document's body	covid:9bbcdc1db7feeedcd55ba7f4e429f2c8358b4221#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/9bbcdc1db7feeedcd55ba7f4e429f2c8358b4221
is schema:about of	named entity 'PORCINE DELTACORONAVIRUS' named entity 'transcription' named entity 'coronaviruses' named entity 'production' named entity 'intestinal' named entity 'LACKING' named entity 'MUTANTS' named entity 'SEV' named entity 'ENDORIBONUCLEASE' named entity 'INDUCED' named entity 'BAB' named entity 'ANTAGONIST' named entity 'ENDORIBONUCLEASE ACTIVITY' named entity 'VERTEBRATE' named entity 'P65' named entity 'INTESTINAL' named entity 'IDENTIFY' named entity 'DIARRHEA' named entity 'ARTERIVIRUSES' named entity 'RESULTS' named entity 'VIRAL REPLICATION' named entity 'WORK' named entity 'BUT' named entity 'ACTIVATION OF TRANSCRIPTION' named entity 'FOUND' named entity 'UNDERSTANDING' covid:arg/9bbcdc1db7feeedcd55ba7f4e429f2c8358b4221 named entity 'SUPPRESS' named entity 'ACTIVATION' named entity 'TRANSCRIPTION FACTOR' named entity 'HIGHLY' named entity 'CAUSING' named entity 'ITS' named entity 'SENDAI VIRUS' named entity 'PATHOGENESIS' named entity 'INTERFERON' named entity 'PRODUCTION' named entity 'INFECTION' named entity 'TAKEN' named entity 'IRF3' named entity 'DISRUPTS' named entity 'HERE' named entity 'CRITICAL' named entity 'DAMAGE' named entity 'SUBUNIT' named entity 'OUR' named entity 'ITS' named entity 'PRODUCTION' named entity 'ENDORIBONUCLEASE ACTIVITY' named entity 'INTERFERON' named entity 'NURSING' named entity 'TRANSCRIPTION' named entity 'CORONAVIRUS' named entity 'ANTAGONISTS' named entity 'IFN' named entity 'PORCINE DELTACORONAVIRUS' named entity 'NOT REQUIRED' named entity 'ENCODED' named entity 'INTERFERON ' named entity 'SWINE' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'TYPE I INTERFERON' named entity 'PROTEIN ' named entity 'PLAYS' named entity 'NUCLEAR TRANSLOCATION' named entity 'PREVIOUS' named entity 'MECHANISM' named entity 'ROLE' named entity 'INDEPENDENT' named entity 'PHOSPHORYLATION' named entity 'CONSERVED' named entity 'transcription factor'

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