About: Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation

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About: Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation
Creator	Collisson, Ellen Drechsler, Yvonne Griggs, Lisa Briles, Worthie Dawes, Maisie
Source	Elsevier; Medline; PMC
abstract	Abstract The chicken MHC has been associated with disease resistance, though the mechanisms are not understood. The functions of macrophages, critical to both innate and acquired immunity, were compared between the more infectious bronchitis virus-resistant B2 and the more infectious bronchitis virus-susceptible B19 lines. In vivo peripheral blood concentrations of monocytes were similar in B2 or B19 homozygous haplotypes. Peripheral blood-derived macrophages were stimulated with poly I:C, simulating an RNA virus, or IFNγ, a cytokine at the interface of innate and adaptive immunity. Not only did B2-derived peripheral monocytes differentiate into macrophages more readily than the B19 monocytes, but as determined by NO production, macrophages from B2 and B2 on B19 genetic background chicks were also significantly more responsive to either stimulant. In conclusion, the correlation with resistance to illness following viral infection may be directly linked to a more vigorous innate immune response.
has issue date	2014-04-01(xsd:dateTime)
bibo:doi	10.3382/ps.2013-03511
bibo:pmid	24706959
has license	els-covid
sha1sum (hex)	9bc9fff56cbd597d71e1e7044eeefc8debdc4578
schema:url	https://doi.org/10.3382/ps.2013-03511
resource representing a document's title	Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation
has PubMed Central identifier	PMC7107093
has PubMed identifier	24706959
schema:publication	Poultry Science
resource representing a document's body	covid:9bc9fff56cbd597d71e1e7044eeefc8debdc4578#body_text
is schema:about of	named entity 'chicken' named entity 'vigorous' named entity 'INTERFERON GAMMA ' named entity 'CHICKS' named entity 'CONCLUSION' named entity 'MECHANISMS' named entity 'ASSOCIATED WITH' named entity 'DERIVED' named entity 'CYTOKINE ' named entity 'UNDERSTOOD' named entity 'RESISTANT' named entity 'HAPLOTYPES' named entity 'STIMULANT' named entity 'DISEASE RESISTANCE' named entity 'FOLLOWING' named entity 'DETERMINED BY' named entity 'MHC' named entity 'DID' named entity 'SIMULATING' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'IN VIVO' named entity 'MAY BE' named entity 'COMPARED' named entity 'B19' named entity 'HOMOZYGOUS' named entity 'ILLNESS' named entity 'GENETIC BACKGROUND' named entity 'RESPONSIVE TO' named entity 'RNA VIRUS' named entity 'INNATE IMMUNE RESPONSE' named entity 'STIMULATED' named entity 'IFN' named entity 'MONOCYTES' named entity 'PERIPHERAL BLOOD' named entity 'DIRECTLY' named entity 'HAPLOTYPES' named entity 'INTERFACE' named entity 'SIMILAR' named entity 'DIFFERENTIATE' named entity 'NO PRODUCTION' named entity 'POLY I' named entity 'ADAPTIVE IMMUNITY' named entity 'RESPONSE' named entity 'MACROPHAGES' named entity 'ACID' named entity 'MHC' named entity 'DEFINED' named entity 'B19' named entity 'EITHER' named entity 'BLOOD CONCENTRATIONS' named entity 'VIRAL INFECTION' named entity 'ACQUIRED IMMUNITY' named entity 'MACROPHAGES' named entity 'CHICKEN' named entity 'PERIPHERAL' named entity 'BUT' named entity 'FUNCTIONS' named entity 'CORRELATION' named entity 'VIGOROUS' named entity 'SUSCEPTIBLE' named entity 'LINES' named entity 'STIMULATION' named entity 'RESISTANCE TO' named entity 'CRITICAL' covid:arg/9bc9fff56cbd597d71e1e7044eeefc8debdc4578 named entity 'B19' named entity 'lines' named entity 'critical' named entity 'haplotypes' named entity 'infectious bronchitis' named entity 'concentrations' named entity 'peripheral' named entity 'infectious bronchitis virus' named entity 'macrophages' named entity 'poly I:C' named entity 'RNA virus' named entity 'adaptive immunity'

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