About: Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Creator	Hajeer, Ali Arabi, Yaseen Alaskar, Ahmed Aljohani, Sameera Khan, Alabdulkareem, Ibrahim Alghoribi, Majed Manie, Balavenkatesh Alajlan, Abdulaziz Albalwi, Mohammed Aldrees, Mohammed Gk, Udayaraja Q2, Anis
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) has continued to cause sporadic outbreaks of severe respiratory tract infection over the last 8 years. METHODS: Complete genome sequencing using next-generation sequencing was performed for MERS-CoV isolates from cases that occurred in Riyadh between 2015 and 2019. Phylogenetic analysis and molecular mutational analysis were carried out to investigate disease severity. RESULTS: A total of eight MERS-CoV isolates were subjected to complete genome sequencing. Phylogenetic analysis resulted in the assembly of 7/8 sequences within lineage 3 and one sequence within lineage 4 showing complex genomic recombination. The isolates contained a variety of unique amino acid substitutions in ORF1ab (41), the N protein (10), the S protein (9) and ORF4b (5). CONCLUSION: Our study shows that MERS-CoV is evolving. The emergence of new variants carries the potential for increased virulence and could impose a challenge to the global health system. We recommend the sequencing every new MERS-CoV isolate to observe the changes in the virus and relate them to clinical outcomes.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1016/j.jiph.2020.06.030
bibo:pmid	32654959
has license	no-cc
sha1sum (hex)	9bcc8c2f80d0d02a52c32bf1617b58487e026075
schema:url	https://doi.org/10.1016/j.jiph.2020.06.030
resource representing a document's title	Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
has PubMed Central identifier	PMC7328614
has PubMed identifier	32654959
schema:publication	J Infect Public Health
resource representing a document's body	covid:9bcc8c2f80d0d02a52c32bf1617b58487e026075#body_text
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