About: Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study

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About: Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study
Creator	Maraschini, Anna Lunghi, Giovanna Ambrogi, Federico Bernazzani, Mara Cantù, Anna Cariani, Lisa Ceriotti, Ferruccio Dodaro, Antonella Gambazza, Simone Oggioni, Massimo Orena, Beatrice Orlandi, Annarosa Pirrone, Alessia Renteria, Sara
source	Medline; PMC
abstract	Background: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. Methods: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR. Results: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed. Conclusions: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.3390/ijerph17155313
bibo:pmid	32718008
has license	cc-by
sha1sum (hex)	9bf15ff68290ab4a36d830dd2ab4b241fffb8f61
schema:url	https://doi.org/10.3390/ijerph17155313
resource representing a document's title	Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study
has PubMed Central identifier	PMC7432921
has PubMed identifier	32718008
schema:publication	Int J Environ Res Public Health
resource representing a document's body	covid:9bf15ff68290ab4a36d830dd2ab4b241fffb8f61#body_text
is schema:about of	named entity 'length' named entity 'Healthcare' named entity 'TURNED' named entity 'INFECTION' named entity 'MILAN' named entity 'SELF-ISOLATION' named entity 'GREATEST' named entity 'CHOICES' covid:arg/9bf15ff68290ab4a36d830dd2ab4b241fffb8f61 named entity 'infection' named entity 'positive' named entity 'swabs' named entity 'work unit' named entity 'SARS-CoV-2' named entity 'Values' named entity 'asymptomatic' named entity 'RT-PCR' named entity 'healthcare workers' named entity 'gene' named entity 'Milan' named entity 'Coronavirus Disease 2019' named entity 'SARS-CoV-2' named entity 'Milan' named entity 'cumulative incidence' named entity 'symptom' named entity 'viral load' named entity 'asymptomatic carriers' named entity 'glycoprotein' named entity 'sputum production' named entity 'RT-PCR' named entity 'RNA' named entity 'viral load' named entity 'infection' named entity 'nasopharyngeal swabs' named entity 'asymptomatic carriers' named entity 'asymptomatic' named entity 'RT-PCR' named entity 'asymptomatic carriers' named entity 'PCR' named entity '37 days' named entity '1, 2' named entity 'RT-PCR' named entity 'false-negative' named entity 'virus' named entity 'anamnestic' named entity 'healthcare workers' named entity 'MERS-CoV' named entity 'virus' named entity 'gene' named entity 'fever' named entity 'respiratory symptoms' named entity 'cough' named entity 'gastrointestinal disorders' named entity 'SARS-CoV-2' named entity 'Hubei Province, China' named entity 'cell culture' named entity 'tested positive' named entity 'epidemiological data' named entity 'SARS-CoV-2' named entity 'nucleocapsid' named entity 'nasopharyngeal swabs' named entity 'Milan' named entity 'analysis of covariance' named entity 'fatigue' named entity 'incubation' named entity 'nucleocapsid' named entity 'SARS-CoV-2' named entity '28 days'

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