About: Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

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About: Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
Creator	Angrand, Pierre-Olivier Azkanaz, Maria Bergink, Steven Huiting, Wouter Vellenga, Edo De Boer, Bauke Kampinga, Harm Ló Pez, Aida Martens, Joost Schuringa, Jan Van Den Boom, Vincent
Source	PMC
abstract	Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subunits, including CBX proteins, but also other chromatin regulators, are found to accumulate in the nucleolus. In parallel, binding of PRC1/2 to target genes is strongly reduced, coinciding with a dramatic loss of H2AK119ub and H3K27me3 marks. Nucleolar-accumulated CBX proteins are immobile, but remarkably both CBX protein accumulation and loss of PRC1/2 epigenetic marks are reversible. This post-heat shock recovery of pan-nuclear CBX protein localization and reinstallation of epigenetic marks is HSP70 dependent. Our findings demonstrate that the nucleolus is an essential protein quality control center, which is indispensable for recovery of epigenetic regulators and maintenance of the epigenome after heat shock.
has issue date	2019-06-14(xsd:dateTime)
bibo:doi	10.7554/elife.45205
bibo:pmid	31199242
has license	cc-by
sha1sum (hex)	9c1b3d1c613332e439a3a925588b2ee3b9bcf18e
schema:url	https://doi.org/10.7554/elife.45205
resource representing a document's title	Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
has PubMed Central identifier	PMC6570483
has PubMed identifier	31199242
resource representing a document's body	covid:9c1b3d1c613332e439a3a925588b2ee3b9bcf18e#body_text
is schema:about of	named entity 'protein' named entity 'marks' named entity 'quality control' named entity 'marks' named entity 'epigenome' named entity 'chromatin' named entity 'REVERSIBLE' named entity 'HERE' named entity 'POLYCOMB GROUP PROTEIN' named entity 'ESSENTIAL' named entity 'TARGET' named entity 'NUCLEAR' named entity 'INTEGRITY' named entity 'HEAT SHOCK' named entity 'PROTEIN ACCUMULATION' named entity 'PAN' named entity 'INDISPENSABLE' named entity 'GENES' named entity 'COMPLEX' named entity 'EPIGENETIC' named entity 'FUNCTIONING' named entity 'PRC1' named entity 'BINDING' named entity 'PROTEIN QUALITY CONTROL' named entity 'RECOVERY' named entity 'REGULATORS' named entity 'MARKS' named entity 'HSP70' named entity 'CELLULAR' named entity 'EPIGENOME' named entity 'NUCLEOLUS' named entity 'EPIGENETIC' named entity 'POLYCOMB' named entity 'HEAT SHOCK' named entity 'PARALLEL' named entity 'NUCLEOLUS' named entity 'CHROMATIN' named entity 'IMMOBILE' named entity 'INCLUDING' named entity 'FOUND' named entity 'RESPONSE TO HEAT SHOCK' named entity 'REDUCED' named entity 'POST' named entity 'CENTER' named entity 'RECOVERY' named entity 'MAINTENANCE' named entity 'H3K27ME3' named entity 'DEPENDENT' named entity 'PROTEIN QUALITY CONTROL' named entity 'PRC2' named entity 'PROTEIN LOCALIZATION' named entity 'CBX' named entity 'REGULATORS' named entity 'ANALYZED' named entity 'VARIOUS' named entity 'ACCUMULATED' named entity 'H2AK119UB' named entity 'OUR' named entity 'FINDINGS' named entity 'PROTEIN ' named entity 'BUT' named entity 'NUCLEOLAR' named entity 'APPROPRIATE' named entity 'PRESERVE' named entity 'PROTEINS' named entity 'LOSS OF' covid:arg/9c1b3d1c613332e439a3a925588b2ee3b9bcf18e named entity 'response' named entity 'Polycomb' named entity 'epigenetic' named entity 'protein' named entity 'heat shock'

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